Age-associated B cells in autoimmune diseases

Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs are expanded during autoimmune disease, including those with systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. The...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2022-08, Vol.79 (8), p.402-402, Article 402
Main Authors: Mouat, Isobel C., Goldberg, Erin, Horwitz, Marc S.
Format: Article
Language:English
Subjects:
Age
Anemia
Antigens
Arthritis
Arthritis, Rheumatoid
Autoantibodies
Autoimmune Diseases
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chronic conditions
Crohn's disease
Cytokines
Encephalomyelitis
Hepatitis
Humans
Infections
Life Sciences
Localization
Lupus
Lupus Erythematosus, Systemic
Lymphocytes
Lymphocytes B
Lymphocytes T
Multiple Sclerosis
Population
Review
Rheumatoid arthritis
Scleroderma
Systemic lupus erythematosus
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Summary:Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs are expanded during autoimmune disease, including those with systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. The exact nature of how ABCs impact disease remains unclear. Here, we review what is known regarding ABC development and distribution during diseases including systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. We discuss possible mechanisms by which ABCs could contribute to disease, including the production of cytokines and autoantibodies or stimulation of T cells. Finally, we speculate on how ABCs might act as mediators between sex, infection, and autoimmune disease, and discuss avenues for further research.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-022-04433-9