Advances in Diagnosis and Therapy for Bladder Cancer

Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. T...

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Bibliographic Details
Published in:Cancers 2022-06, Vol.14 (13), p.3181
Main Authors: Hu, Xinzi, Li, Guangzhi, Wu, Song
Format: Article
Language:English
Subjects:
Accuracy
Biomarkers
Biopsy
Bladder cancer
Cancer
Cancer therapies
Chemotherapy
Cognition
Diagnosis
DNA methylation
Drug delivery
Endoscopy
Immunotherapy
Lasers
Light
Medical prognosis
Meta-analysis
Review
Spectrum analysis
Surveillance
Tomography
Tumors
Urine
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Summary:Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. The development of innovative enhanced cystoscopy techniques (optical techniques, imaging systems) and tumor biomarkers-based non-invasive urine screening (DNA methylation-based urine test) would dramatically improve the accuracy of tumor detection, reducing the risk of recurrence and progression of BCa. Moreover, intravesical instillation and systemic therapeutic strategies (cocktail therapy, immunotherapy, vaccine therapy, targeted therapy) also provide plentiful measures to break the predicament of BCa. Several exploratory clinical studies, including novel surgical approaches, pharmaceutical compositions, and bladder preservation techniques, emerged continually, which are supposed to be promising candidates for BCa clinical treatment. Here, recent advances and prospects of diagnosis, intravesical or systemic treatment, and novel drug delivery systems for BCa therapy are reviewed in this paper.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14133181