The Role of Ultrasound in the Evaluation of Inguinal Lymph Nodes in Patients with Vulvar Cancer: A Systematic Review and Meta-Analysis

• Published in: Cancers 2022-06, Vol.14 (13), p.3082
• Main Authors: Verri, Debora, Moro, Francesca, Fragomeni, Simona Maria, Zaçe, Drieda, Bove, Sonia, Pozzati, Federica, Gui, Benedetta, Scambia, Giovanni, Testa, Antonia Carla, Garganese, Giorgia
• Format: Article
• Language: English
• Subjects: Biopsy; Breast cancer; Computed tomography; Genital cancers; Histology; Lymph nodes; Lymphatic system; Magnetic resonance imaging; Medical prognosis; Melanoma; Meta-analysis; Metastases; Metastasis; Patients; Risk assessment; Skin cancer; Surgery; Systematic Review; Tomography; Tumors; Ultrasonic imaging; Ultrasound; Womens health
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers14133082

Objective. To determine the efficacy of ultrasound in assessing the inguinal lymph nodes in patients with vulvar cancer. Methods. A systematic review of published research up to October 2020 that compares the results of ultrasound to determine groin node status with histology was conducted. All study types that reported primary data on the role of ultrasound in the evaluation of groin lymph nodes in vulvar cancer were included in the systematic review. Data retrieved from the included studies were pooled in random-effects meta-analyses. Results. After the screening and selection process, eight articles were deemed pertinent for inclusion in the systematic review and meta-analysis. The random-effects model showed a pooled Se of 0.85 (95% CI: 0.81–0.89), Sp of 0.86 (95% CI: 0.81–0.91), PPV of 0.65 (95% CI: 0.54–0.79) and NPV of 0.92 (95% CI: 0.91–0.94). There was a pooled LR+ and LR− of 6.44 (95% CI: 3.72–11.4) and 0.20 (95% CI: 0.14–0.27), respectively. The pooled accuracy was 0.85 (95% CI: 0.80–0.91). Conclusions. Although the studies had small sample sizes, this review represents the best summary of the data so far. Ultrasound has revealed high sensitivity and high negative predictive value in the assessment of nodal status in vulvar cancer.