Primary nervous system lymphoma in cats

Here we characterize the neuroanatomic distribution, neuropathology, and immunophenotype of 10 cases of primary nervous system lymphoma in cats. Cases were retrospectively searched from 2 academic institutions. Selected cases were reviewed and subjected to immunohistochemistry (IHC) for CD3, CD20, a...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2022-07, Vol.34 (4), p.712-717
Main Authors: Rissi, Daniel R., McHale, Brittany J., Miller, Andrew D.
Format: Article
Language:English
Subjects:
Animals
Brain - pathology
Brief Reports
Cat Diseases - pathology
Cats
Lymphoma - pathology
Lymphoma - veterinary
Lymphoma, B-Cell - pathology
Lymphoma, B-Cell - veterinary
Lymphoma, T-Cell - veterinary
Retrospective Studies
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Summary:Here we characterize the neuroanatomic distribution, neuropathology, and immunophenotype of 10 cases of primary nervous system lymphoma in cats. Cases were retrospectively searched from 2 academic institutions. Selected cases were reviewed and subjected to immunohistochemistry (IHC) for CD3, CD20, and Pax5. The mean age of affected cats was 9.1 y, and no sex or breed predilection was observed. The most common clinical sign was ataxia (8 cases). Gross changes reported in 8 cases consisted of white-to-tan masses (7 cases) or swelling (1 case) within the neuroparenchyma (5 cases) or epidural spaces (3 cases). Histologically, intraparenchymal lymphomas occurred in the gray and white matter or perivascular spaces (7 cases); extraparenchymal lymphomas (6 cases) consisted of neoplastic cell infiltration of the perivascular spaces in the leptomeninges, choroid plexus, or epidural spaces. Nerve lymphomas were diffusely infiltrative. Tumors occurred in the brain (4 cases), spinal cord and nerves (3 cases), spinal cord (2 cases), and brain, spinal cord, and nerves (1 case). IHC was consistent with a B-cell lymphoma in 5 cases and with a T-cell lymphoma in 5 cases.
ISSN:1040-6387
1943-4936
DOI:10.1177/10406387221090281