Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts

Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (13), p.7019
Main Authors: Sawicka, Diana, Hryniewicka, Agnieszka, Gohal, Sylwia, Sadowska, Anna, Pryczynicz, Anna, Guzińska-Ustymowicz, Katarzyna, Sokołowska, Emilia, Morzycki, Jacek W., Car, Halina
Format: Article
Language:English
Subjects:
5-Fluorouracil
Acids
Apoptosis
Cancer therapies
Cell cycle
Chains
Chemotherapy
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Fibroblasts
Fungi
Gene expression
Metabolism
Metastasis
Necrosis
Salts
Steroids
Tumors
Xenografts
Xenotransplantation
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Summary:Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction in the viability and metabolic activity was obtained in vitro for DLD-1 and HT-29 cell lines when treated with tested salts. The results showed that the activities of tested agents are directly related to the alkyl chain length, where S6–S8 compounds were the most cytotoxic against the DLD-1 line and S4–S10 against HT-29. The research performed on the xenograft model of mice demonstrated a lower tendency of tumor growth in the group receiving compound S6, compared with the group receiving 5-fluorouracil (5-FU). Obtained results indicate the activity of S6 in the induction of apoptosis and necrosis in induced colorectal cancer. LCA-based imidazolium salts may be candidates for chemotherapeutic agents against colorectal cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137019