Evaluation of Sirolimus Dosing in Neonates and Infants With Lymphatic Disorders: A Case Series

OBJECTIVELiterature in pediatric patients suggests dosing sirolimus 1.6 mg/m2/day divided twice daily for lymphatic disorders with limited evidence available for dosing in neonates and infants. The objective of this research was to determine the sirolimus dose required to achieve therapeutic trough...

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Bibliographic Details
Published in:The journal of pediatric pharmacology and therapeutics 2022-01, Vol.27 (5), p.447-451
Main Authors: Serio, Jordan, Gattoline, Sarah, Collier, Hailey, Bustin, Anna
Format: Article
Language:English
Subjects:
Brief Report
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Summary:OBJECTIVELiterature in pediatric patients suggests dosing sirolimus 1.6 mg/m2/day divided twice daily for lymphatic disorders with limited evidence available for dosing in neonates and infants. The objective of this research was to determine the sirolimus dose required to achieve therapeutic trough concentrations in infants with lymphatic disorders at Children's Hospital of Philadelphia. METHODSThis retrospective review included patients
ISSN:1551-6776
2331-348X
DOI:10.5863/1551-6776-27.5.447