Simultaneous Substitution of Fe and Sr in Beta-Tricalcium Phosphate: Synthesis, Structural, Magnetic, Degradation, and Cell Adhesion Properties

β-tricalcium phosphate is a promising bone graft substitute material with biocompatibility and high osteoinductivity. However, research on the ideal degradation and absorption for better clinical application remains a challenge. Now, we focus on modifying physicochemical properties and improving bio...

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Bibliographic Details
Published in:Materials 2022-07, Vol.15 (13), p.4702
Main Authors: Kim, So-Min, Yoo, Kyung-Hyeon, Kim, Hyeonjin, Kim, Yong-Il, Yoon, Seog-Young
Format: Article
Language:English
Subjects:
Adhesion tests
Biocompatibility
Biological properties
Biomedical materials
Calcium phosphates
Cell adhesion
Cell adhesion & migration
Degradation
Diamagnetism
Ferromagnetism
Fourier transforms
Grafting
Grafts
Hyperthermia
Infrared spectroscopy
Investigations
Magnetic properties
Materials substitution
Nitrates
Photoelectrons
Radiation
Spectrum analysis
Strontium
Substitute bone
Tissue engineering
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Summary:β-tricalcium phosphate is a promising bone graft substitute material with biocompatibility and high osteoinductivity. However, research on the ideal degradation and absorption for better clinical application remains a challenge. Now, we focus on modifying physicochemical properties and improving biological properties through essential ion co-substitution (Fe and Sr) in β-TCPs. Fe- and Sr-substituted and Fe/Sr co-substituted β-TCP were synthesized by aqueous co-precipitation with substitution levels ranging from 0.2 to 1.0 mol%. The β-TCP phase was detected by X-ray diffraction and Fourier transform infrared spectroscopy. Changes in Ca–O and P–O bond lengths of the co-substituted samples were observed through X-ray photoelectron spectroscopy. The results of VSM represent the M-H graph having a combination of diamagnetic and ferromagnetic properties. A TRIS–HCl solution immersion test showed that the degradation and resorption functions act synergistically on the surface of the co-substituted sample. Cell adhesion tests demonstrated that Fe enhances the initial adhesion and proliferation behavior of hDPSCs. The present work suggests that Fe and Sr co-substitution in β-TCP can be a candidate for promising bone graft materials in tissue engineering fields. In addition, the possibility of application of hyperthermia for cancer treatment can be expected.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma15134702