Emerging role of an immunomodulatory protein secretoglobin 3A2 in human diseases

Secretoglobin (SCGB) 3A2 was first identified in 2001 as a protein exhibiting similarities in amino acid sequence and gene structure to SCGB1A1, a multi-functional cytokine-like molecule highly expressed in airway epithelial Club cells that was the first identified and extensively studied member of...

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Published in:Pharmacology & therapeutics (Oxford) 2022-08, Vol.236, p.108112-108112, Article 108112
Main Authors: Kimura, Shioko, Yokoyama, Shigetoshi, Pilon, Aprile L., Kurotani, Reiko
Format: Article
Language:English
Subjects:
Anti-cancer
Anti-fibrotic
Anti-inflammatory
CC10
CCSP
Cytokines - metabolism
Growth factor
Humans
Lung diseases
Respiratory System - metabolism
SCGB1A1
SCGB3A1
Secretoglobins - genetics
Secretoglobins - metabolism
UGRP1
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Summary:Secretoglobin (SCGB) 3A2 was first identified in 2001 as a protein exhibiting similarities in amino acid sequence and gene structure to SCGB1A1, a multi-functional cytokine-like molecule highly expressed in airway epithelial Club cells that was the first identified and extensively studied member of the SCGB gene superfamily. SCGB3A2 is a small secretory protein of ~10 kDa that forms a dimer and a tetramer. SCGB3A2 is predominantly expressed in airway epithelial Club cells, and has anti-inflammatory, growth factor, anti-fibrotic, and anti-cancer activities that influence various lung diseases. This review summarizes the current understanding of SCGB3A2 biological functions and its role in human diseases with emphasis on its mechanisms of actions and signaling pathway.
ISSN:0163-7258
1879-016X
1879-016X
DOI:10.1016/j.pharmthera.2022.108112