Human chorionic gonadotropin-β promotes pancreatic cancer progression via the epithelial mesenchymal transition signaling pathway

BackgroundThe human chorionic gonadotropin free beta-subunit (hCGβ) is ectopically produced in various epithelial cancers and is associated with poor prognoses. However, its molecular mechanism remains unclear. In this study, we examined the biological role of hCGβ in pancreatic cancer progression....

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Published in:Journal of gastrointestinal oncology 2022-06, Vol.13 (3), p.1384-1394
Main Authors: Uesato, Yasunori, Kawamata, Futoshi, Ishino, Shinichiro, Ono, Shinichiro, Tamashiro, Koichi, Koyama, Hirofumi, Takatsuki, Mitsuhisa
Format: Article
Language:English
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Summary:BackgroundThe human chorionic gonadotropin free beta-subunit (hCGβ) is ectopically produced in various epithelial cancers and is associated with poor prognoses. However, its molecular mechanism remains unclear. In this study, we examined the biological role of hCGβ in pancreatic cancer progression. MethodsTissue specimens of 30 patients with pancreatic cancer were examined immunohistochemically to investigate the relationship between hCGβ expression and clinicopathological features. We also evaluated the molecular effects of hCGβ-downregulated pancreatic cell lines. ResultsTotal of 21 cases were positive for immunostaining, and 17 of 25 metastatic lymph nodes were positive. hCGβ expression levels were correlated with pancreatic cancer T and N factors. hCGβ expression was significantly associated with poor overall and recurrence-free survival (P
ISSN:2078-6891
2219-679X
DOI:10.21037/jgo-21-907