Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effe...

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Bibliographic Details
Published in:Drug delivery 2022-12, Vol.29 (1), p.2130-2161
Main Authors: Li, Bingqian, Shao, Huili, Gao, Lei, Li, Huan, Sheng, Huagang, Zhu, Liqiao
Format: Article
Language:English
Subjects:
Apoptosis
Cancer therapies
Cell cycle
Cell growth
Chemotherapy
chemotherapy drugs
Chinese medicine
combination therapy
Drug delivery systems
Drugs
Nano-drug co-delivery system
nanocarrier
natural active ingredients
Natural products
Pancreatic cancer
Pharmacy
R&D
Research & development
Review
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Summary:Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2022.2094498