Epigenetic mechanisms of inner ear development

•Development of the mammalian inner ear is orchestrated by epigenetic factors.•DNA methylation, histone modifications, and chromatin remodeling all influence various aspects of inner ear development.•Emerging genomic technologies reveal epigenetic mechanisms of inner ear development at single cell r...

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Bibliographic Details
Published in:Hearing research 2022-12, Vol.426, p.108440-108440, Article 108440
Main Authors: Balendran, Vinodh, Ritter, K. Elaine, Martin, Donna M.
Format: Article
Language:English
Subjects:
Chromatin remodeling
Cochlea
DNA methylation
Hair cells
Histone modification
Otic placode
Spiral ganglia
Supporting cells
Vestibular system
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Summary:•Development of the mammalian inner ear is orchestrated by epigenetic factors.•DNA methylation, histone modifications, and chromatin remodeling all influence various aspects of inner ear development.•Emerging genomic technologies reveal epigenetic mechanisms of inner ear development at single cell resolution. Epigenetic factors are critically important for embryonic and postnatal development. Over the past decade, substantial technological advancements have occurred that now permit the study of epigenetic mechanisms that govern all aspects of inner ear development, from otocyst patterning to maturation and maintenance of hair cell stereocilia. In this review, we highlight how three major classes of epigenetic regulation (DNA methylation, histone modification, and chromatin remodeling) are essential for the development of the inner ear. We highlight open avenues for research and discuss how new tools enable the employment of epigenetic factors in regenerative and therapeutic approaches for hearing and balance disorders.
ISSN:0378-5955
1878-5891
DOI:10.1016/j.heares.2022.108440