Evaluation of the Glymphatic System Using the DTI-ALPS Index in Patients with Spontaneous Intracerebral Haemorrhage

Objective. To investigate the function of the human glymphatic system (GS) in patients with spontaneous intracerebral haemorrhage (sICH) using diffusion tensor imaging analysis along with the perivascular space (DTI-ALPS). Methods. Twenty patients with sICH and 31 healthy controls (HCs) were recruit...

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Published in:Oxidative medicine and cellular longevity 2022-07, Vol.2022, p.1-7
Main Authors: Zhang, Chao, Sha, Jingyun, Cai, Lulu, Xia, Yingying, Li, Danyang, Zhao, Houliang, Meng, Chong, Xu, Kai
Format: Article
Language:English
Subjects:
Alzheimer's disease
Hemorrhage
Ischemia
Magnetic resonance imaging
Metabolism
Mortality
Pathophysiology
Patients
Software
Stroke
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Summary:Objective. To investigate the function of the human glymphatic system (GS) in patients with spontaneous intracerebral haemorrhage (sICH) using diffusion tensor imaging analysis along with the perivascular space (DTI-ALPS). Methods. Twenty patients with sICH and 31 healthy controls (HCs) were recruited for DTI and susceptibility-weighted imaging scanning. The diffusivity along the perivascular spaces, as well as the projection fibres and association fibres, was evaluated separately. The DTI-ALPS index of each subject was also calculated. Two-sample t-tests and paired t-tests were performed to analyse the difference in ALPS scores between patients and HCs, as well as that between the lesion side and contralateral side. Pearson correlation analysis was used to observe the relationship between disease duration and GS function. Results. The DTI-ALPS index on the lesion side was significantly lower than that of the contralateral side in patients with sICH (p
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/2694316