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Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment

Objective. This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic s...

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Published in:Computational and mathematical methods in medicine 2022-07, Vol.2022, p.4982047-12
Main Authors: Xu, Linlin, Li, Lin, Zu, Jianyu, Huang, Xinyuan, Tian, Lin, Sun, Yingjie, Diao, Yugang
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container_title Computational and mathematical methods in medicine
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creator Xu, Linlin
Li, Lin
Zu, Jianyu
Huang, Xinyuan
Tian, Lin
Sun, Yingjie
Diao, Yugang
description Objective. This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5°C for 30 min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer’s restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods. Results. Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment. Conclusion. The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. Early LR-restrictive fluid replacement promotes the balance of inflammatory response and the recovery of immunosuppressive state, resists oxidative stress, stabilizes the balance of coagulation and fibrinolysis, improves coagulation function, and relieves organ injury.
doi_str_mv 10.1155/2022/4982047
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This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5°C for 30 min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer’s restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods. Results. Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment. Conclusion. The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. Early LR-restrictive fluid replacement promotes the balance of inflammatory response and the recovery of immunosuppressive state, resists oxidative stress, stabilizes the balance of coagulation and fibrinolysis, improves coagulation function, and relieves organ injury.</description><identifier>ISSN: 1748-670X</identifier><identifier>EISSN: 1748-6718</identifier><identifier>DOI: 10.1155/2022/4982047</identifier><identifier>PMID: 35844441</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Animals ; Crystalloid Solutions ; Disease Models, Animal ; Fluid Therapy - methods ; Hydroxyethyl Starch Derivatives - pharmacology ; Immunity ; Multiple Organ Failure ; Rats ; Rats, Sprague-Dawley ; Ringer's Lactate ; Shock, Hemorrhagic - therapy</subject><ispartof>Computational and mathematical methods in medicine, 2022-07, Vol.2022, p.4982047-12</ispartof><rights>Copyright © 2022 Linlin Xu et al.</rights><rights>Copyright © 2022 Linlin Xu et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-334295ab7edc50c82ceb41bafb64760461dfec052e2768a8b6693566e2d9987d3</citedby><cites>FETCH-LOGICAL-c420t-334295ab7edc50c82ceb41bafb64760461dfec052e2768a8b6693566e2d9987d3</cites><orcidid>0000-0002-5139-9002 ; 0000-0003-0323-7460 ; 0000-0003-4509-9035 ; 0000-0002-6564-9332 ; 0000-0002-4976-5552 ; 0000-0003-4484-4785 ; 0000-0001-7262-5788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35844441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tang, Min</contributor><creatorcontrib>Xu, Linlin</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Zu, Jianyu</creatorcontrib><creatorcontrib>Huang, Xinyuan</creatorcontrib><creatorcontrib>Tian, Lin</creatorcontrib><creatorcontrib>Sun, Yingjie</creatorcontrib><creatorcontrib>Diao, Yugang</creatorcontrib><title>Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment</title><title>Computational and mathematical methods in medicine</title><addtitle>Comput Math Methods Med</addtitle><description>Objective. This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5°C for 30 min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer’s restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods. Results. Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment. Conclusion. The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. 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Li, Lin ; Zu, Jianyu ; Huang, Xinyuan ; Tian, Lin ; Sun, Yingjie ; Diao, Yugang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-334295ab7edc50c82ceb41bafb64760461dfec052e2768a8b6693566e2d9987d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Crystalloid Solutions</topic><topic>Disease Models, Animal</topic><topic>Fluid Therapy - methods</topic><topic>Hydroxyethyl Starch Derivatives - pharmacology</topic><topic>Immunity</topic><topic>Multiple Organ Failure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ringer's Lactate</topic><topic>Shock, Hemorrhagic - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Linlin</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Zu, Jianyu</creatorcontrib><creatorcontrib>Huang, Xinyuan</creatorcontrib><creatorcontrib>Tian, Lin</creatorcontrib><creatorcontrib>Sun, Yingjie</creatorcontrib><creatorcontrib>Diao, Yugang</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Computational and mathematical methods in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Linlin</au><au>Li, Lin</au><au>Zu, Jianyu</au><au>Huang, Xinyuan</au><au>Tian, Lin</au><au>Sun, Yingjie</au><au>Diao, Yugang</au><au>Tang, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment</atitle><jtitle>Computational and mathematical methods in medicine</jtitle><addtitle>Comput Math Methods Med</addtitle><date>2022-07-06</date><risdate>2022</risdate><volume>2022</volume><spage>4982047</spage><epage>12</epage><pages>4982047-12</pages><issn>1748-670X</issn><eissn>1748-6718</eissn><abstract>Objective. This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment. Methods. SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5°C for 30 min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer’s restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods. Results. Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment. Conclusion. The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. Early LR-restrictive fluid replacement promotes the balance of inflammatory response and the recovery of immunosuppressive state, resists oxidative stress, stabilizes the balance of coagulation and fibrinolysis, improves coagulation function, and relieves organ injury.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35844441</pmid><doi>10.1155/2022/4982047</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-5139-9002</orcidid><orcidid>https://orcid.org/0000-0003-0323-7460</orcidid><orcidid>https://orcid.org/0000-0003-4509-9035</orcidid><orcidid>https://orcid.org/0000-0002-6564-9332</orcidid><orcidid>https://orcid.org/0000-0002-4976-5552</orcidid><orcidid>https://orcid.org/0000-0003-4484-4785</orcidid><orcidid>https://orcid.org/0000-0001-7262-5788</orcidid><oa>free_for_read</oa></addata></record>
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subjects Animals
Crystalloid Solutions
Disease Models, Animal
Fluid Therapy - methods
Hydroxyethyl Starch Derivatives - pharmacology
Immunity
Multiple Organ Failure
Rats
Rats, Sprague-Dawley
Ringer's Lactate
Shock, Hemorrhagic - therapy
title Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment
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