Effects of SARS-CoV-2 infections in patients with cancer on mortality, ICU admission and incidence: a systematic review with meta-analysis involving 709,908 participants and 31,732 cancer patients

Background Cancer patients constitute one of the highest-risk patient groups during the COVID-19 pandemic. In this study, it was aimed to perform a systematic review and meta-analysis to determine both the incidence and ICU (Intensive Care Unit) admission rates and mortality in SARS-CoV-2 infected c...

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Published in:Journal of cancer research and clinical oncology 2023-07, Vol.149 (7), p.2915-2928
Main Authors: Arayici, Mehmet Emin, Kipcak, Nazlican, Kayacik, Ufuktan, Kelbat, Cansu, Keskin, Deniz, Kilicarslan, Muhammed Emin, Kilinc, Ahmet Veli, Kirgoz, Sumeyye, Kirilmaz, Anil, Kizilkaya, Melih Alihan, Kizmaz, Irem Gaye, Kocak, Enes Berkin, Kochan, Enver, Kocpinar, Begum, Kordon, Fatmanur, Kurt, Batuhan, Ellidokuz, Hulya
Format: Article
Language:English
Subjects:
Cancer
Cancer Research
Comorbidity
COVID-19
Hematology
Internal Medicine
Medicine
Medicine & Public Health
Meta-analysis
Mortality
Oncology
Pandemics
Risk factors
Severe acute respiratory syndrome coronavirus 2
Systematic review
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Summary:Background Cancer patients constitute one of the highest-risk patient groups during the COVID-19 pandemic. In this study, it was aimed to perform a systematic review and meta-analysis to determine both the incidence and ICU (Intensive Care Unit) admission rates and mortality in SARS-CoV-2 infected cancer patients. Methods The PRISMA guidelines were closely followed during the design, analysis, and reporting of this systematic review and meta-analysis. A comprehensive literature search was performed for the published papers in PubMed/Medline, Scopus, medRxiv, Embase, and Web of Science (WoS) databases. SARS-CoV-2 infection pooled incidence in the cancer populations and the risk ratio (RR) of ICU admission rates/mortality in cancer and non-cancer groups, with 95% confidence intervals (CIs), were calculated using the random-effects model. Results A total of 58 studies, involving 709,908 participants and 31,732 cancer patients, were included in this study. The incidence in cancer patients was calculated as 8% (95% CI: 8–9%). Analysis results showed that mortality and ICU admission rate was significantly higher in patients with cancer (RR = 2.26, 95% CI: 1.94–2.62, P  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-022-04191-y