Surgery vs non-surgery in cutaneous melanoma based on SEER database: A cross-sectional study

This study was to assess the survival outcome of cutaneous melanoma (CM) patients with surgery vs non-surgery through inverse probability of treatment weighting (IPTW) using the propensity score. Patients diagnosed as CM were selected from the Surveillance, Epidemiology, and End Results Program (SEE...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-03, Vol.100 (12), p.e25120-e25120
Main Authors: Liu, Yingnan, Yang, Dazhi, Fu, Xiaokuan, Sun, Yulong, Xiong, Hongtao, Fang, Xichi, Zhuang, Yongqing
Format: Article
Language:English
Subjects:
Adult
Aged
Cohort Studies
Cross-Sectional Studies
Dermatologic Surgical Procedures - mortality
Female
Humans
Male
Melanoma - mortality
Melanoma - pathology
Melanoma - surgery
Melanoma, Cutaneous Malignant
Middle Aged
Neoplasm Staging
Observational Study
Propensity Score
Proportional Hazards Models
SEER Program
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Treatment Outcome
Young Adult
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Summary:This study was to assess the survival outcome of cutaneous melanoma (CM) patients with surgery vs non-surgery through inverse probability of treatment weighting (IPTW) using the propensity score. Patients diagnosed as CM were selected from the Surveillance, Epidemiology, and End Results Program (SEER) database. The survival outcome was estimated and compared by IPTW using the propensity score. Totally 2203 CM patients were identified, in which 1921 cases received surgical treatment (surgery group), while 282 cases didn't (non-surgery group). The median survival time of surgery and non-surgery groups was respectively 150 months and 15 months (unmatched cohort), 70 months and 40 months (matched cohort) and 130 months vs. 75 months (IPTW-weighted cohort). Compared with the non-surgery group, the surgery group had a lower risk of death in unmatched [hazard ratio (HR): 0.647, 95% confidence interval (CI): 0.509-0.821, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000025120