Adolescent sleep shapes social novelty preference in mice

Sleep disturbances frequently occur in neurodevelopmental disorders such as autism, but the developmental role of sleep is largely unexplored, and a causal relationship between developmental sleep defects and behavioral consequences in adulthood remains elusive. Here, we show that in mice, sleep dis...

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Bibliographic Details
Published in:Nature neuroscience 2022-07, Vol.25 (7), p.912-923
Main Authors: Bian, Wen-Jie, Brewer, Chelsie L., Kauer, Julie A., de Lecea, Luis
Format: Article
Language:English
Subjects:
14/1
14/19
14/35
38/44
631/378/1385
631/378/3919
64/60
9/10
9/74
Adolescents
Animal Genetics and Genomics
Animals
Autism
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Child development
Dopamine
Dopamine receptors
Dopaminergic Neurons - physiology
Mice
Microfilament Proteins
Nerve Tissue Proteins
Neurobiology
Neurodevelopmental disorders
Neurosciences
Sleep
Sleep - physiology
Social Behavior
Social factors
Ventral Tegmental Area - physiology
Ventral tegmentum
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Summary:Sleep disturbances frequently occur in neurodevelopmental disorders such as autism, but the developmental role of sleep is largely unexplored, and a causal relationship between developmental sleep defects and behavioral consequences in adulthood remains elusive. Here, we show that in mice, sleep disruption (SD) in adolescence, but not in adulthood, causes long-lasting impairment in social novelty preference. Furthermore, adolescent SD alters the activation and release patterns of dopaminergic neurons in the ventral tegmental area (VTA) in response to social novelty. This developmental sleep function is mediated by balanced VTA activity during adolescence; chemogenetic excitation mimics, whereas silencing rescues, the social deficits of adolescent SD. Finally, we show that in Shank3 -mutant mice, improving sleep or rectifying VTA activity during adolescence ameliorates adult social deficits. Together, our results identify a critical role of sleep and dopaminergic activity in the development of social interaction behavior. Bian et al. show that sleep during adolescence is crucial for shaping the preference for novel social stimulation in adulthood. This developmental role of sleep is mediated by balanced levels of VTA activity during adolescent brain development.
ISSN:1097-6256
1546-1726
1546-1726
DOI:10.1038/s41593-022-01076-8