The HBV Specially-Related Long Noncoding RNA HBV-SRL Involved in the Pathogenesis of Hepatocellular Carcinoma

Hepatitis B virus (HBV) is one of the major risk factors for HCC (hepatocellular carcinoma) occurrence with a diverse role in the pathogenesis of HCC. More works need to be performed to elucidate a more thorough understanding of the molecular mechanisms involving in HBV-induced HCC, although some me...

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Published in:Journal of oncology 2022-07, Vol.2022, p.9034105-11
Main Authors: Zhang, Cunzhen, Lu, Lei, Xin, Haibei, Zhang, Minfeng, Ding, Zhiwen, Li, Qiaomei, Chen, Kuang, Hu, Minggen, Liu, Shupeng, Li, Nan
Format: Article
Language:English
Subjects:
Antisense RNA
DNA methylation
Drug resistance
Gene expression
Genomes
Genomics
Health aspects
Hepatitis B
Hepatoma
Infection
Infections
Liver cancer
Medical prognosis
Metastasis
Pathogenesis
Prognosis
Proteins
Roles
Tumors
Viral infections
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container_issue
container_start_page 9034105
container_title Journal of oncology
container_volume 2022
creator Zhang, Cunzhen
Lu, Lei
Xin, Haibei
Zhang, Minfeng
Ding, Zhiwen
Li, Qiaomei
Chen, Kuang
Hu, Minggen
Liu, Shupeng
Li, Nan
description Hepatitis B virus (HBV) is one of the major risk factors for HCC (hepatocellular carcinoma) occurrence with a diverse role in the pathogenesis of HCC. More works need to be performed to elucidate a more thorough understanding of the molecular mechanisms involving in HBV-induced HCC, although some mechanisms such as genome integration have been reported. In the present study, aberrantly expressed lncRNAs were identified between HCC tumor tissues with or without HBV infection. Among these molecules, HBV specially-related long noncoding RNA (HBV-SRL) was further found to correlate with poor prognosis and a shorter overall survival time in HCC patients with HBV infection. Additionally, HBV-SRL was found function as oncogene by upregulating the NF-κB2 expression. These data suggest that HBV infection altered gene expression pattern in liver cells which contributed to HBV-related HCC development, and HBV-SRL may serve as a new molecular marker or potential therapeutic target of HBV-related HCC.
doi_str_mv 10.1155/2022/9034105
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subjects Antisense RNA
DNA methylation
Drug resistance
Gene expression
Genomes
Genomics
Health aspects
Hepatitis B
Hepatoma
Infection
Infections
Liver cancer
Medical prognosis
Metastasis
Pathogenesis
Prognosis
Proteins
Roles
Tumors
Viral infections
title The HBV Specially-Related Long Noncoding RNA HBV-SRL Involved in the Pathogenesis of Hepatocellular Carcinoma
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