Chronic Effects of Modeled Myocardial Infarction, Thoracic Trauma, and Denervation of Hind Limb on Rheographic Parameters of Rat Femoral Arteries In Situ

• Published in: Bulletin of experimental biology and medicine 2022-07, Vol.173 (3), p.306-311
• Main Authors: Tikhomirova, L. N., Karpova, M. N., Klishina, N. Yu, Kuznetsova, L. V., Kukushkin, M. L., Makarov, A. D., Revenko, S. V., Tarakanov, I. A.
• Format: Article
• Language: English
• Subjects: Animal experimentation; Arteries; Biomedical and Life Sciences; Biomedicine; Cell Biology; Chronic effects; Denervation; Femoral artery; Femur; Heart attack; Heart attacks; Internal Medicine; Laboratory Medicine; Leg; Myocardial infarction; Neuralgia; Oscillations; Pathology; Rodents; Thorax; Trauma
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05539-7

In experiments on narcotized male rats ( n =85), the mean electroimpedance Z and peak-to-peak magnitudes (the swing ranges) of passive (ΔZ p ) and active (ΔZ a ) pulsatile electroimpedance oscillations of isolated segment of femoral arteries were determined in situ . These rheographic parameters (RP) were measured in intact animals and in those with modeled chronic myocardial infarction, chronic denervation of the right hind leg, as well as in rats subjected to sham operations to mimic denervation or infarction (with thoracic trauma). The rats with modeled myocardial infarction demonstrated decreasing trends of all RP. In sham-operated rats with thoracic trauma, ΔZ p increased significantly on postsurgery months 2-4 by 4.3 times in comparison with the control. No essential correlation was found in denervated rats between RP of any femoral artery and severity of neuropathic pain syndrome assessed by autotomy of the operated leg. In these rats, the mean electroimpedance Z of any femoral artery was significantly greater than the control level. They demonstrated especially high values of ΔZ p with significant difference between ΔZ p of innervated and denervated hind leg. In denervated rats, ΔZ a was significantly greater than the control value without significant difference between ΔZ a of both femoral arteries. The paradoxically great increase of ΔZ p (100- and 50-fold for innervated and denervated legs, respectively) and a significant 3-fold increment of ΔZ a in both hind legs provoked by denervation of one of them are discussed in relation to searching for the ways of systemic influences on vascular network in clinics and experiments.