Heart rate variability and adrenal size provide clues to sudden cardiac death in hospitalized COVID-19 patients

To examine the association between a measure of heart rate variability and sudden cardiac death (SCD) in COVID-19 patients. Patients with SARS-COV-2 infection admitted to Columbia University Irving Medical Center who died between 4/25/2020 and 7/14/2020 and had an autopsy were examined for root mean...

Full description

Saved in:
Bibliographic Details
Published in:Journal of critical care 2022-10, Vol.71, p.154114-154114, Article 154114
Main Authors: Ranard, Benjamin L., Megjhani, Murad, Terilli, Kalijah, Yarmohammadi, Hirad, Ausiello, John, Park, Soojin
Format: Article
Language:English
Subjects:
Autopsies
Autopsy
Biomarkers
Blood clots
Cardiomyopathy
Coronaviruses
COVID-19
Critical care
Death, Sudden, Cardiac - epidemiology
Heart attacks
Heart Rate
Hospitalization
Humans
Mortality
Myocarditis
Patients
Pulmonary arteries
Pulmonary embolisms
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Steroids
Telemetry
Ultrasonic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To examine the association between a measure of heart rate variability and sudden cardiac death (SCD) in COVID-19 patients. Patients with SARS-COV-2 infection admitted to Columbia University Irving Medical Center who died between 4/25/2020 and 7/14/2020 and had an autopsy were examined for root mean square of successive differences (RMSSD), organ weights, and evidence of SCD. Thirty COVID-19 patients were included and 12 had SCD. The RMSSD over 7 days without vs with SCD was median 0.0129 (IQR 0.0074–0.026) versus 0.0098 (IQR 0.0056–0.0197), p < 0.0001. The total adjusted adrenal weight of the non-SCD group was 0.40 g/kg (IQR 0.35–0.55) versus 0.25 g/kg (IQR 0.21–0.31) in the SCD group, p = 0.0007. Hospitalized patients with COVID-19 who experienced SCD had lower parasympathetic activity (RMSSD) and smaller sized adrenal glands. Further research is required to replicate these findings.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2022.154114