The search for anti‐oxytotic/ferroptotic compounds in the plant world

Oxytosis/ferroptosis is a form of non‐apoptotic regulated cell death characterized by glutathione (GSH) depletion and dysregulated production of mitochondrial ROS that results in lethal lipid peroxidation. As the significance of oxytosis/ferroptosis to age‐associated human diseases is now beginning...

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Bibliographic Details
Published in:British journal of pharmacology 2021-09, Vol.178 (18), p.3611-3626
Main Authors: Soriano‐Castell, David, Liang, Zhibin, Maher, Pamela, Currais, Antonio
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apoptosis
Catalysts
Cell death
Dementia
drug discovery
Ferroptosis
Glutathione
Glutathione - metabolism
Humans
Lipid Peroxidation
Medicinal plants
Mitochondria
Mitochondria - metabolism
Neurodegenerative diseases
Oxidative stress
phenotypic screening
plant secondary metabolites
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Summary:Oxytosis/ferroptosis is a form of non‐apoptotic regulated cell death characterized by glutathione (GSH) depletion and dysregulated production of mitochondrial ROS that results in lethal lipid peroxidation. As the significance of oxytosis/ferroptosis to age‐associated human diseases is now beginning to be appreciated, the development of innovative approaches to identify novel therapeutics that target the oxytosis/ferroptosis pathway could not be more timely. Due to their sessile nature, plants are exposed to a variety of stresses that trigger physiological changes similar to those found in oxytosis/ferroptosis. As such, they have evolved a rich array of chemical strategies to deal with those challenging conditions. This review details a drug discovery approach for identifying potent inhibitors of oxytosis/ferroptosis from plants for the treatment of Alzheimer's disease and related dementias, thereby highlighting the tremendous potential of plant‐based research for developing new medicines while simultaneously being a catalyst for sustainability.
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.15517