Thalamic Influence on Slow Wave Slope Renormalization During Sleep

• Published in: Annals of neurology 2021-11, Vol.90 (5), p.821-833
• Main Authors: Jaramillo, Valeria, Jendoubi, Jasmine, Maric, Angelina, Mensen, Armand, Heyse, Natalie C., Eberhard‐Moscicka, Aleksandra K., Wiest, Roland, Bassetti, Claudio L. A., Huber, Reto
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Apnea; Cognition; Cognition - physiology; Daytime; Disorders of Excessive Somnolence - physiopathology; EEG; Electroencephalography; Electroencephalography - methods; Functional testing; Humans; Male; Middle Aged; Polysomnography - methods; Reduction; Sleep; Sleep - physiology; Sleep and wakefulness; Sleep disorders; Sleepiness; Stroke; Stroke - physiopathology; Synaptic strength; Thalamus; Thalamus - physiopathology; Young Adult
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.26217

Objective Slow waves are thought to mediate an overall reduction in synaptic strength during sleep. The specific contribution of the thalamus to this so‐called synaptic renormalization is unknown. Thalamic stroke is associated with daytime sleepiness, along with changes to sleep electroencephalography and cognition, making it a unique “experiment of nature” to assess the relationship between sleep rhythms, synaptic renormalization, and daytime functions. Methods Sleep was studied by polysomnography and high‐density electroencephalography over 17 nights in patients with thalamic (n = 12) and 15 nights in patients with extrathalamic (n = 11) stroke. Sleep electroencephalographic overnight slow wave slope changes and their relationship with subjective daytime sleepiness, cognition, and other functional tests were assessed. Results Thalamic and extrathalamic patients did not differ in terms of age, sleep duration, or apnea–hypopnea index. Conversely, overnight slope changes were reduced in a large cluster of electrodes in thalamic compared to extrathalamic stroke patients. This reduction was related to increased daytime sleepiness. No significant differences were found in other functional tests between the 2 groups. Interpretation In patients with thalamic stroke, a reduction in overnight slow wave slope change and increased daytime sleepiness was found. Sleep‐ and wake‐centered mechanisms for this relationship are discussed. Overall, this study suggests a central role of the thalamus in synaptic renormalization. ANN NEUROL 2021;90:821–833