Psoas muscle depletion during preoperative chemotherapy for advanced gastric cancer has a negative impact on long‐term outcomes after gastrectomy

Aim The significance of sarcopenia in cancers has been widely recognized. However, few studies have focused on chronological changes in sarcopenia in cancer patients. This study aimed to clarify the clinical significance of changes in the psoas muscle area before and after preoperative chemotherapy....

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Published in:Asia-Pacific journal of clinical oncology 2022-02, Vol.18 (1), p.61-69
Main Authors: Horii, Nobutoshi, Kosaka, Takashi, Fujiwara, Ryo, Sato, Sho, Akiyama, Hirotoshi, Kunisaki, Chikara, Endo, Itaru
Format: Article
Language:English
Subjects:
Chemotherapy
Gastrectomy
Gastric cancer
Gastrointestinal surgery
Humans
Male
Medical prognosis
Multivariate analysis
Original
Patients
preoperative chemotherapy
Prognosis
Psoas muscle
psoas muscle index
Psoas Muscles
Retrospective Studies
Sarcopenia
Sarcopenia - chemically induced
Stomach Neoplasms - drug therapy
Stomach Neoplasms - surgery
Survival
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Summary:Aim The significance of sarcopenia in cancers has been widely recognized. However, few studies have focused on chronological changes in sarcopenia in cancer patients. This study aimed to clarify the clinical significance of changes in the psoas muscle area before and after preoperative chemotherapy. Methods This study included 39 patients who underwent gastrectomy followed by preoperative chemotherapy for advanced gastric cancer between January 2010 and December 2016 in our hospital. The psoas muscle area was measured at the umbilical level before and after chemotherapy, and the relationship between its chronological changes and the long‐term prognosis was examined. Results Patients were classified into two groups according to changes in the psoas muscle area before and after preoperative chemotherapy: remarkable muscle depletion and normal groups. No significant differences were observed in clinicopathological factors. Notably, the remarkable muscle depletion group included significantly more male patients (P = .018) and showed a high weight loss rate (P 
ISSN:1743-7555
1743-7563
DOI:10.1111/ajco.13514