Quantifying Bone Marrow Fat Fraction and Iron by MRI for Distinguishing Aplastic Anemia from Myelodysplastic Syndromes

Background Bone marrow of patients with aplastic anemia (AA) is different from that of patients with myelodysplastic syndrome (MDS) and is difficult to identify by blood examination. IDEAL‐IQ (iterative decomposition of water and fat with echo asymmetry and least‐squares estimation) imaging might be...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2021-12, Vol.54 (6), p.1754-1760
Main Authors: Zeng, Zhaolong, Ma, Xiangzheng, Guo, Yifan, Ye, Baodong, Xu, Maosheng, Wang, Wei
Format: Article
Language:English
Subjects:
Anemia
Aplastic anemia
Bone marrow
bone marrow fat
Field strength
Intelligence
Iron
Magnetic resonance imaging
magnetic resonance quantitation
Medical imaging
Myelodysplastic syndrome
Myelodysplastic syndromes
Population studies
Spine
Statistical analysis
Statistical tests
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Summary:Background Bone marrow of patients with aplastic anemia (AA) is different from that of patients with myelodysplastic syndrome (MDS) and is difficult to identify by blood examination. IDEAL‐IQ (iterative decomposition of water and fat with echo asymmetry and least‐squares estimation) imaging might be able to quantify fat fraction (FF) and iron content in bone tissues. Purpose To determine if IDEAL‐IQ measurements of bone marrow FF and iron content can distinguish between patients with AA and MDS. Study Type Retrospective. Population Fifty‐seven patients with AA, 21 patients with MDS, and 24 healthy controls. Field Strength/Sequence 3.0 T, IDEAL‐IQ sequence. Assessment Three independent observers evaluated the IDEAL‐IQ images and measured FF and R2* in the left posterior superior iliac spine. Statistical Tests Kruskal–Wallis test, linear correlations, and Bland–Altman analysis were used. A P‐value of
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.27769