Prevalence of neurocognitive and perceived speech deficits in patients with head and neck cancer before treatment: Associations with demographic, behavioral, and disease‐related factors

Background Neurocognition and speech, relevant domains in head and neck cancer (HNC), may be affected pretreatment. However, the prevalence of pretreatment deficits and their possible concurrent predictors are poorly understood. Methods Using an HNC prospective cohort (Netherlands Quality of Life an...

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Published in:Head & neck 2022-02, Vol.44 (2), p.332-344
Main Authors: Piai, Vitória, Jansen, Femke, Dahlslätt, Kristoffer, Verdonck‐de Leeuw, Irma M., Prins, Judith, Leemans, René, Terhaard, Chris H. J., Langendijk, Johannes A., Baatenburg de Jong, Robert J., Smit, Johannes H., Takes, Robert, Kessels, Roy
Format: Article
Language:English
Subjects:
Cognition
Cognitive ability
Cohort Studies
Cross-Sectional Studies
fluency
Head & neck cancer
head and neck cancer
Head and Neck Neoplasms - complications
Humans
Larynx
neurocognitive assessment
Original
Patients
pretreatment symptoms
Prevalence
Prospective Studies
Quality of Life
Speech
Tumors
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Summary:Background Neurocognition and speech, relevant domains in head and neck cancer (HNC), may be affected pretreatment. However, the prevalence of pretreatment deficits and their possible concurrent predictors are poorly understood. Methods Using an HNC prospective cohort (Netherlands Quality of Life and Biomedical Cohort Study, N ≥ 444) with a cross‐sectional design, we investigated the estimated prevalence of pretreatment deficits and their relationship with selected demographic, behavioral, and disease‐related factors. Results Using objective assessments, rates of moderate‐to‐severe neurocognitive deficit ranged between 4% and 8%. From patient‐reported outcomes, 6.5% of patients reported high levels of cognitive failures and 46.1% reported speech deficits. Patient‐reported speech functioning was worse in larynx compared to other subsites. Other nonspeech outcomes were unrelated to any variable. Patient‐reported neurocognitive and speech functioning were modestly correlated, especially in the larynx group. Conclusions These findings indicate that a subgroup of patients with HNC shows pretreatment deficits, possibly accentuated in the case of larynx tumors.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26930