Additional burden of iron deficiency in heart failure patients beyond the cardio‐renal anaemia syndrome: findings from the BIOSTAT‐CHF study

Aims Whereas the combination of anaemia and chronic kidney disease (CKD) has been extensively studied in patients with heart failure (HF), the contribution of iron deficiency (ID) to this dysfunctional interplay is unknown. We aimed to assess clinical associates and pathophysiological pathways relat...

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Bibliographic Details
Published in:European journal of heart failure 2022-01, Vol.24 (1), p.192-204
Main Authors: Alnuwaysir, Ridha I.S., Grote Beverborg, Niels, Hoes, Martijn F., Markousis‐Mavrogenis, George, Gomez, Karla A., Wal, Haye H., Cleland, John G.F., Dickstein, Kenneth, Lang, Chim C., Ng, Leong L., Ponikowski, Piotr, Anker, Stefan D., Veldhuisen, Dirk J., Voors, Adriaan A., Meer, Peter
Format: Article
Language:English
Subjects:
Anaemia
Anemia - complications
Anemia - epidemiology
Anemia, Iron-Deficiency - complications
Anemia, Iron-Deficiency - epidemiology
Biomarkers
Cardio-Renal Syndrome - epidemiology
Cardiorenal
Chronic kidney disease
Comorbidities
Heart failure
Heart Failure - complications
Heart Failure - epidemiology
Humans
Iron Deficiencies
Iron deficiency
Male
Quality of Life
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Summary:Aims Whereas the combination of anaemia and chronic kidney disease (CKD) has been extensively studied in patients with heart failure (HF), the contribution of iron deficiency (ID) to this dysfunctional interplay is unknown. We aimed to assess clinical associates and pathophysiological pathways related to ID in this multimorbid syndrome. Methods and results We studied 2151 patients with HF from the BIOSTAT‐CHF cohort. Patients were stratified based on ID (transferrin saturation
ISSN:1388-9842
1879-0844
DOI:10.1002/ejhf.2393