Radiotherapy for hormone-sensitive prostate cancer with synchronous low burden of distant metastases

Purpose The DEGRO Expert Commission on Prostate Cancer has revised the indication for radiation therapy of the primary prostate tumor in patients with synchronous distant metastases with low metastatic burden. Methods The current literature in the PubMed database was reviewed regarding randomized ev...

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Published in:Strahlentherapie und Onkologie 2022-08, Vol.198 (8), p.683-689
Main Authors: Müller, Arndt-Christian, Aebersold, Daniel M., Albrecht, Clemens, Böhmer, Dirk, Flentje, Michael, Ganswindt, Ute, Ghadjar, Pirus, Schmidt-Hegemann, Nina-Sophie, Höcht, Stefan, Hölscher, Tobias, Niehoff, Peter, Pinkawa, Michael, Sedlmayer, Felix, Wolf, Frank, Zamboglou, Constantinos, Zips, Daniel, Wiegel, Thomas
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Metastasis
Nodes
Oncology
Prostate cancer
Radiation therapy
Radiotherapy
Review
Review Article
Risk management
Standard of care
Subgroups
Survival
Tumors
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Summary:Purpose The DEGRO Expert Commission on Prostate Cancer has revised the indication for radiation therapy of the primary prostate tumor in patients with synchronous distant metastases with low metastatic burden. Methods The current literature in the PubMed database was reviewed regarding randomized evidence on radiotherapy of the primary prostate tumor with synchronous low metastatic burden. Results In total, two randomized trials were identified. The larger study, the STAMPEDE trial, demonstrated an absolute survival benefit of 8% after 3 years for patients with low metastatic burden treated with standard of care (SOC) and additional radiotherapy (RT) (EQD2 ≤ 72 Gy) of the primary tumor. Differences in the smaller Horrad trial were not statistically significant, although risk reduction in the subgroup (
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-022-01961-y