Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson’s Disease

Parkinson’s disease (PD) is a neurological disorder in which oxidative stress and reactive oxygen species productions are proposed to be involved in its pathogenesis. Despite considerable advancement in Selenium’s (Se) molecular biology and metabolism, we do not know much about the cell type-specifi...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-07, Vol.37 (3), p.257-266
Main Authors: Salaramoli, Sanaz, Joshaghani, Hamidreza, Hashemy, Seyed Isaac
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Biochemistry
Biomedical and Life Sciences
Calcium signalling
Chemistry/Food Science
Glutathione peroxidase
Life Sciences
Lipid peroxidation
Microbiology
Movement disorders
Neurodegenerative diseases
Neurons
Oxidative stress
Parkinson's disease
Pathogenesis
Pathology
Physiological aspects
Reactive oxygen species
Review
Review Article
Selenium
Selenoproteins
Signal transduction
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Summary:Parkinson’s disease (PD) is a neurological disorder in which oxidative stress and reactive oxygen species productions are proposed to be involved in its pathogenesis. Despite considerable advancement in Selenium’s (Se) molecular biology and metabolism, we do not know much about the cell type-specific pattern of Se distribution in the brain of PD humans and experimental animals. Although, there is plenty of evidence around the role of Se deficiency in PD’s pathogenesis impacting lipid peroxidation and reducing glutathione (GSH) and glutathione peroxidase (GPX). It has been suggested that Se has an inducible role in selenium-dependent GPX activity in PD animals and humans. However, calcium as a second messenger regulates the neuron cells’ essential activities, but its overloading leads to cellular oxidative stress and apoptosis. Therefore, Se’s antioxidant role can affect calcium signaling and alleviate its complications. There are signs of Se and Selenoproteins incorporation in protecting stress oxidative in various pathways. In conclusion, there is convincing proof for the crucial role of Se and Calcium in PD pathogenesis.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-022-01031-1