Pediatric Patients With Sickle Cell Disease at a Public Hospital: Nutrition, Compliance and Early Experience With L-Glutamine Therapy

Hydration and hydroxyurea (HU) can modify sickle cell disease (SCD) severity. Optimal nutrition and L-glutamine (Gln) may provide further amelioration. Reviews of medical records and nutrition surveys were used to investigate severity of pediatric patients with SCD in relation to nutrition, growth,...

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Bibliographic Details
Published in:In vivo (Athens) 2022-07, Vol.36 (4), p.1761-1768
Main Authors: Gotesman, Moran, Elgar, Guy, Santiago, Laura Hernandez, Alvarez, Abigail, Pak, Youngju, Lin, Henry J, Lasky, Joseph L, Panosyan, Eduard H
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Sickle Cell - drug therapy
Antisickling Agents - therapeutic use
Child
Female
Glutamine - therapeutic use
Hospitals, Public
Humans
Hydroxyurea - therapeutic use
Male
Nutritional Status
Patient Compliance
Prealbumin
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Summary:Hydration and hydroxyurea (HU) can modify sickle cell disease (SCD) severity. Optimal nutrition and L-glutamine (Gln) may provide further amelioration. Reviews of medical records and nutrition surveys were used to investigate severity of pediatric patients with SCD in relation to nutrition, growth, hematologic parameters, and diseasemodifying agents. Among 25 females and 25 males (9.1±7 years), beta-globin genotypes were: HbSS/Sβ°, 60%; HbSC, 32%; HbSβ , 8%. The mean number of annual pain crises (APC) was 0.97±1.1. APCs increased ≥2-fold as HbF dropped to
ISSN:0258-851X
1791-7549
1791-7549
DOI:10.21873/invivo.12889