The Role of PPAR-gamma C161T Polymorphism in Colorectal Cancer Susceptibility

BACKGROUND/AIMThis study aimed to determine the role of the peroxisome proliferator-activated receptor-gamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC). PATIENTS AND METHODSPPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polyme...

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Published in:In vivo (Athens) 2022-07, Vol.36 (4), p.1911-1915
Main Authors: KURNAZ-GOMLEKSIZ, OZLEM, TORUN, BAHAR CANBAY, ISBIR, TURGAY, BULUT, TURKER, SOKUCU, NECMETTIN, YILMAZ-AYDOGAN, HULYA, CANBAY, EMEL
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Language:English
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Summary:BACKGROUND/AIMThis study aimed to determine the role of the peroxisome proliferator-activated receptor-gamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC). PATIENTS AND METHODSPPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in patients with CRC (n=101) and controls (n=238). RESULTSThe T161 allele (CT+TT genotypes) of PPARg C161T polymorphism was associated with CRC development (p
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.12911