Characteristics of HBV Novel Serum Markers across Distinct Phases in Treatment-Naïve Chronic HBV-Infected Patients

Background and aims. To investigate the clinical implications of serum HBV RNA, serum hepatitis B core-related antigen (HBcrAg), and quantitative anti-HBc in treatment-naïve patients with chronic HBV infection. Methods. A total of 111 patients in total from different disease phases were recruited, i...

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Bibliographic Details
Published in:Disease markers 2022-07, Vol.2022, p.1-13
Main Authors: Liao, Hao, Li, Le, Zheng, Wei V., Zou, Jun, Yu, Guangxin, Si, Lanlan, Ge, Feilin, Zhou, Tao, Ji, Dong, Chen, Xiangmei, Xu, Dongping, Cheng, Guanxun, Liu, Yan, Chen, Junhui
Format: Article
Language:English
Subjects:
Antigens
Biomarkers
Biopsy
Chronic infection
Circular DNA
Deoxyribonucleic acid
DNA
DNA polymerase
Health services
Hepatitis B
Hepatitis B e antigen
Hospitals
Immune clearance
Immunoassay
Infections
Inflammation
Liver
Liver cancer
Liver diseases
Patients
Phases
Ribonucleic acid
RNA
Serology
Serum levels
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Summary:Background and aims. To investigate the clinical implications of serum HBV RNA, serum hepatitis B core-related antigen (HBcrAg), and quantitative anti-HBc in treatment-naïve patients with chronic HBV infection. Methods. A total of 111 patients in total from different disease phases were recruited, including 21 in immune-tolerant (IT) phase, 49 in immune-clearance (IC) phases, 29 in immune-control or low replicative (LR) phase, and 12 in reactivation phases. Serum HBV RNA, anti-HBc, HBcrAg, and intrahepatic covalently closed circular DNA (cccDNA) were quantified and each of these indicator’s correlation with liver inflammation was analyzed. Results. HBeAg-positive individuals had significant higher serum levels of HBV RNA and HBcrAg than those who were HBeAg negative, similar to that of serum HBV DNA. Comparatively, HBV RNA (r =0.79, P
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/4133283