Simvastatin in the Treatment of Colorectal Cancer: A Review

Drug repositioning and drug reuse are the heated topics in the field of oncology in recent years. These two concepts refer to seeking effective drugs for cancer that are not originally intended to treat cancer. The survival benefits are then analyzed by combining the re-positioned drugs with convent...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022, Vol.2022, p.3827933-6
Main Authors: Zang, Hongliang, Yang, Wei, Tian, Xiaofeng
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Cancer
Cancer therapies
Cardiovascular diseases
Cell cycle
Cell growth
Clinical trials
Colorectal cancer
Colorectal carcinoma
Cyclin-dependent kinases
Drug addiction
Drug dosages
Epidermal growth factor
Hyperlipidemia
Kinases
Metastases
Metastasis
Mortality
Proteins
Radiation therapy
Review
Signal transduction
Simvastatin
Stem cells
Tumors
Vascular endothelial growth factor
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Summary:Drug repositioning and drug reuse are the heated topics in the field of oncology in recent years. These two concepts refer to seeking effective drugs for cancer that are not originally intended to treat cancer. The survival benefits are then analyzed by combining the re-positioned drugs with conventional cancer treatment methods. Simvastatin is a clinically commonly used hyperlipidemia drug and exerts the effect of preventing cardiovascular diseases. Recent studies have found that simvastatin has great potential in the treatment of colorectal cancer, and a large number of clinical studies have used simvastatin as an adjuvant drug to help treat metastatic colorectal cancer.
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/3827933