Effect of remimazolam tosilate on early cognitive function in elderly patients undergoing upper gastrointestinal endoscopy

Background and Aim Remimazolam tosilate (RT) is under evaluation as a sedative for endoscopic procedures. Herein, we aimed to evaluate safety including cognition recovery of RT administered in elderly patients undergoing upper gastrointestinal endoscopy and assess its safety dosage. Methods Ninety‐n...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2022-03, Vol.37 (3), p.576-583
Main Authors: Tan, Yingjie, Ouyang, Wen, Tang, Yongzhong, Fang, Ning, Fang, Chao, Quan, Chengxuan
Format: Article
Language:English
Subjects:
Aged
Anesthesia
Benzodiazepines - adverse effects
Benzodiazepines - pharmacology
Cognition - drug effects
Cognition - physiology
Cognitive ability
Cognitive function
Elderly patients
Endoscopic sedation
Endoscopy
Endoscopy, Gastrointestinal
Executive function
Hemodynamics
Humans
Hypnotics and Sedatives - adverse effects
Hypnotics and Sedatives - pharmacology
Hypotension
Neuropsychological Tests
Original ‐ Endoscopy
Propofol
Propofol - pharmacology
Remimazolam tosilate
Upper gastrointestinal endoscopy
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Summary:Background and Aim Remimazolam tosilate (RT) is under evaluation as a sedative for endoscopic procedures. Herein, we aimed to evaluate safety including cognition recovery of RT administered in elderly patients undergoing upper gastrointestinal endoscopy and assess its safety dosage. Methods Ninety‐nine patients presenting for upper gastrointestinal endoscopy were randomized to receive 0.1 mg/kg RT (R1) or 0.2 mg/kg RT (R2), or propofol (P). Cognitive functions (memory, attention, and executive function) were measured via neuropsychological tests conducted before sedation and 5 min after recovery to full alertness. Adverse events were also assessed. Results There were no statistical differences between postoperative and baseline results for R1 group and P group, whereas those for R2 group revealed worsened postoperative cognitive functions (immediate recall and short delay recall) than baseline (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.15761