Caspase 8 Expression Patterns in Meningiomas: A Tissue Microarray Digital Image Analysis

Background: Caspases (cysteine-aspartic proteases) represent a family of enzymes that critically influence cell homeostasis by being involved in inflammation and apoptosis mechanisms. Meningiomas demonstrate the most common intracranial primary central nervous system tumors in adults worldwide.Aim:...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-06, Vol.14 (6), p.e26182-e26182
Main Authors: Roukas, Dimitrios, Kouzoupis, Anastasios, Spyropoulou, Despoina, Tsiambas, Evangelos, Mastronikolis, Stylianos, Falidas, Evangelos, Tsouvelas, George, Ragos, Vasileios, Lazaris, Andreas C, Kavantzas, Nikolaos
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Apoptosis
Automation
Brain cancer
Brain research
Chromosomes
Neurosurgery
Oncology
Pathology
Protein expression
Proteins
Tumors
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Summary:Background: Caspases (cysteine-aspartic proteases) represent a family of enzymes that critically influence cell homeostasis by being involved in inflammation and apoptosis mechanisms. Meningiomas demonstrate the most common intracranial primary central nervous system tumors in adults worldwide.Aim: Our purpose was to explore the role of caspase 8 expression in meningiomas’ pathological features.Materials and methods: A total of 50 meningioma cases were included in the study, comprising a broad spectrum of histopathological sub-types. An immunohistochemistry assay was applied on tissue microarray cores followed by digital image analysis.Results: Overexpression of caspase 8 protein was observed in 21/50 (42%) cases, whereas the rest of them (29/50, 58%) demonstrated moderate to low levels of the molecule. Caspase 8 overall expression was statistically significantly correlated to grade of the examined tumors and to mitotic index (p=0.001,p=0.002, respectively).Conclusions: Caspase 8 aberrant expression is observed in meningiomas associated with their differentiation grade and mitotic activity. Targeted therapeutic strategies focused on enhancing caspase 8 expression and also inducing the overall apoptotic activity should be a very promising approach in rationally handling sub-groups of meningioma patients.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.26182