ITGA7, CD133, ALDH1 are inter‐correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer

Aim Integrin alpha 7 (ITGA7) regulates cancer stemness and metastasis in several malignancies, while its role in cervical cancer is obscure. Therefore, the current study aimed to investigate the correlation among ITGA7, cluster of differentiation 133 (CD133), and aldehyde dehydrogenase isoform 1 (AL...

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Published in:The journal of obstetrics and gynaecology research 2022-04, Vol.48 (4), p.1011-1018
Main Authors: Yuan, Na, Wang, Lei, Xi, Qiang, Zou, Niandong, Zhang, Xianyu, Lu, Xiurong, Zhang, Zhilin
Format: Article
Language:English
Subjects:
AC133 Antigen - metabolism
Aldehyde dehydrogenase
Aldehyde Dehydrogenase 1 Family - metabolism
aldehyde dehydrogenase isoform 1
Antigens, CD - metabolism
Biomarkers, Tumor - metabolism
Cervical cancer
cluster of differentiation 133
Female
Humans
Immunohistochemistry
integrin alpha 7
Integrins - metabolism
Lymph nodes
Lymphatic Metastasis - pathology
Lymphatic system
Metastases
Metastasis
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Original
Prognosis
Survival
Tumors
Uterine Cervical Neoplasms - pathology
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Summary:Aim Integrin alpha 7 (ITGA7) regulates cancer stemness and metastasis in several malignancies, while its role in cervical cancer is obscure. Therefore, the current study aimed to investigate the correlation among ITGA7, cluster of differentiation 133 (CD133), and aldehyde dehydrogenase isoform 1 (ALDH1), as well as their relation to tumor features and survival in cervical cancer patients. Methods A total of 133 surgical cervical cancer patients were enrolled. Tumor ITGA7, CD133, and ALDH1 expressions were determined by immunohistochemistry (IHC). Furthermore, the clinicopathological features, disease‐free survival (DFS), and overall survival (OS) were collected. Results ITGA7 expression positively related to CD133 expression (p = 0.040) and ALDH1 expression (p 
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15163