Growth factor expression is enhanced, and extracellular matrix proteins are depressed in healing skin wounds in septic patients compared with healthy controls

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2022-03, Vol.130 (3), p.155-168
• Main Authors: Jaurila, Henna, Koskela, Marjo, Koivukangas, Vesa, Gäddnäs, Fiia, Salo, Tuula, Ala‐Kokko, Tero I.
• Format: Article
• Language: English
• Subjects: Aged; Blistering; Case-Control Studies; ECM; Epithelium; Epithelium - metabolism; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - metabolism; Female; Fibroblast growth factor 2; growth factor; Growth factors; Humans; Immune response; Immune system; immunohistochemistry; Intercellular Signaling Peptides and Proteins - metabolism; Laminin; Male; Membrane proteins; Middle Aged; Nerve Tissue Proteins - metabolism; Organs; Original; Proteins; Sepsis; Sepsis - metabolism; Skin; Skin - metabolism; skin wound; Suction; Syndecan; Syndecans - metabolism; Tenascin; Tenascin - metabolism; Transforming growth factor-b; Up-Regulation - physiology; Wound healing; Wound Healing - physiology
• ISSN: 0903-4641; 1600-0463
• DOI: 10.1111/apm.13175

Sepsis manifests as a dysregulated immune response to infection, damaging organs. Skin has a critical role in protecting the body. In sepsis, skin wound healing is impaired. The mechanisms behind it have been poorly studied. In this study, suction blister wounds were induced on intact abdominal skin in 15 septic patients. A single blister wound was biopsied from each patient and from 10 healthy controls. Immunohistochemical staining of growth factors and extracellular matrix (ECM) proteins was performed. Significance (p