Glycerol monolaurate attenuated immunological stress and intestinal mucosal injury by regulating the gut microbiota and activating AMPK/Nrf2 signaling pathway in lipopolysaccharide-challenged broilers

This study was conducted to investigate the effects of glycerol monolaurate (GML) on lipopolysaccharide (LPS)-induced immunological stress and intestinal mucosal injury in broilers and its underlying mechanisms. A total of 144 one-d-old Arbor Acres broilers were allocated to a 2 × 2 factorial arrang...

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Bibliographic Details
Published in:Animal Nutrition 2022-09, Vol.10, p.347-359
Main Authors: Kong, Linglian, Wang, Zhenhua, Xiao, Chuanpi, Zhu, Qidong, Song, Zhigang
Format: Article
Language:English
Subjects:
Adenosine monophosphate-activated protein kinase
Antioxidation
Glycerol monolaurate
Gut microbiota
Inflammation
Lipopolysaccharide challenge
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Summary:This study was conducted to investigate the effects of glycerol monolaurate (GML) on lipopolysaccharide (LPS)-induced immunological stress and intestinal mucosal injury in broilers and its underlying mechanisms. A total of 144 one-d-old Arbor Acres broilers were allocated to a 2 × 2 factorial arrangement involving dietary treatment (0 or 1,200 mg/kg dietary GML) and LPS challenge (injected with saline or Escherichia coli LPS on d 16, 18, and 20). Samples were collected on d 21. The results revealed that dietary GML augmented serum immunoglobulin A ( P  = 0.009) and immunoglobulin G ( P  
ISSN:2405-6545
2405-6383
DOI:10.1016/j.aninu.2022.06.005