Cholinergic brain network deficits associated with vestibular sensory conflict deficits in Parkinson’s disease: correlation with postural and gait deficits

To examine regional cerebral vesicular acetylcholine transporter (VAChT) ligand [ 18 F]fluoroethoxybenzovesamicol ([ 18 F]-FEOBV) PET binding in Parkinson’ disease (PD) patients with and without vestibular sensory conflict deficits (VSCD). To examine associations between VSCD-associated cholinergic...

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Bibliographic Details
Published in:Journal of Neural Transmission 2022-08, Vol.129 (8), p.1001-1009
Main Authors: Bohnen, Nicolaas I., Kanel, Prabesh, Roytman, Stiven, Scott, Peter J. H., Koeppe, Robert A., Albin, Roger L., Kerber, Kevin A., Müller, Martijn L. T. M.
Format: Article
Language:English
Subjects:
Aged
Brain - diagnostic imaging
Brain - metabolism
Cholinergic Agents
Female
Gait
Gait Disorders, Neurologic - diagnostic imaging
Gait Disorders, Neurologic - etiology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neurology and Preclinical Neurological Studies - Original Article
Neurosciences
Parkinson Disease - complications
Parkinson Disease - diagnostic imaging
Parkinson Disease - metabolism
Psychiatry
Vesicular Acetylcholine Transport Proteins - metabolism
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Summary:To examine regional cerebral vesicular acetylcholine transporter (VAChT) ligand [ 18 F]fluoroethoxybenzovesamicol ([ 18 F]-FEOBV) PET binding in Parkinson’ disease (PD) patients with and without vestibular sensory conflict deficits (VSCD). To examine associations between VSCD-associated cholinergic brain deficits and postural instability and gait difficulties (PIGD). PD persons (M70/F22; mean age 67.6 ± 7.4 years) completed clinical assessments for imbalance, falls, freezing of gait (FoG), modified Romberg sensory conflict testing, and underwent VAChT PET. Volumes of interest (VOI)-based analyses included detailed thalamic and cerebellar parcellations. VSCD-associated VAChT VOI selection used stepwise logistic regression analysis. Vesicular monoamine transporter type 2 (VMAT2) [ 11 C]dihydrotetrabenazine (DTBZ) PET imaging was available in 54 patients. Analyses of covariance were performed to compare VSCD-associated cholinergic deficits between patients with and without PIGD motor features while accounting for confounders. PET sampling passed acceptance criteria in 73 patients. This data-driven analysis identified cholinergic deficits in five brain VOIs associating with the presence of VSCD: medial geniculate nucleus (MGN) ( P  
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-022-02523-3