Persistent blood DNA methylation changes one year after SARS-CoV-2 infection

We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year afte...

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Bibliographic Details
Published in:Clinical epigenetics 2022-07, Vol.14 (1), p.94-94, Article 94
Main Authors: Balnis, Joseph, Madrid, Andy, Hogan, Kirk J, Drake, Lisa A, Adhikari, Anish, Vancavage, Rachel, Singer, Harold A, Alisch, Reid S, Jaitovich, Ariel
Format: Article
Language:English
Subjects:
Acute Disease
Alzheimer's disease
Brief Report
Coronaviruses
COVID-19
COVID-19 - genetics
CpG Islands
DNA
DNA Methylation
Epigenetics
Gene expression
Genes
Genomes
Health aspects
Humans
Illnesses
Infection
Infections
Leukocytes
Methylation
Mortality
Ontology
Pandemics
Pathophysiology
Patients
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year after discharge. Of the 1505 acute illness-induced differentially methylated regions (DMRs) previously identified, we found 71 regions with persisted differentially methylated, with an average of 7 serial CpG positions per DMR. Sixty-four DMRs persisted hypermethylated, and 7 DMR persisted hypomethylated. These data are the first reported evidence that DNA methylation changes in circulating leukocytes endure long after recovery from acute illness.
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-022-01313-8