Osteoporosis management and falls prevention in patients with haemophilia: Review of haemophilia guidelines

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia 2022-05, Vol.28 (3), p.388-396
• Main Authors: Petkovic, Madison J., Tran, Huyen A, Ebeling, Peter R., Zengin, Ayse
• Format: Article
• Language: English
• Subjects: bone mineral density; fall; fracture; guideline; haemophilia; osteoporosis; Review; Reviews
• ISSN: 1351-8216; 1365-2516
• DOI: 10.1111/hae.14540

Introduction Patients with haemophilia (PWH) have a high prevalence of osteoporosis, falls and fractures at all ages. The role of haemophilia itself may contribute to low bone mineral density (BMD) due to coagulation factor deficiency. Guidelines for the management of osteoporosis, fracture and fall risk may help to reduce fracture and fall risk, and delay osteoporosis onset. Aim We aim to review current haemophilia guidelines regarding osteoporosis prevention, screening, diagnosis and management, and fall prevention. Method A database search (Ovid MEDLINE) revealed two haemophilia guidelines (World and British) published within the last ten years. Local Australian haemophilia guidelines were identified through a manual search. Results All haemophilia guidelines were found to contain inadequate recommendations for osteoporosis management and fall prevention due to a lack of evidence in the literature. Conclusion Further studies are required to assess the trajectory of bone health in PWH, the mechanism of bone loss in PWH, and the effectiveness of weight‐bearing exercises, interventions for fall prevention, screening programmes, and use of anti‐osteoporosis medications in PWH across the lifecourse.