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CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication
Summary Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute to tea flavours, but little is known about the regulation of trichome development. Here, we showed that CsMYB1 is involved in the regulation of trichome formation and galloy...
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| Published in: | The New phytologist 2022-05, Vol.234 (3), p.902-917 |
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| container_title | The New phytologist |
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| creator | Li, Penghui Fu, Jiamin Xu, Yujie Shen, Yihua Zhang, Yanrui Ye, Zhili Tong, Wei Zeng, Xiangsheng Yang, Jihong Tang, Dingkun Li, Ping Zuo, Hao Wu, Qiong Xia, Enhua Wang, Shucai Zhao, Jian |
| description | Summary
Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute to tea flavours, but little is known about the regulation of trichome development.
Here, we showed that CsMYB1 is involved in the regulation of trichome formation and galloylated cis‐catechins biosynthesis in tea plants. The variations in CsMYB1 expression levels are closely correlated with trichome indexes and galloylated cis‐catechins contents in tea plant populations. Genome resequencing showed that CsMYB1 may be selected in modern tea cultivars, since a 192‐bp insertion in CsMYB1 promoter was found exclusively in modern tea cultivars but not in the glabrous wild tea Camellia taliensis. Several enhancers in the 192‐bp insertion increased CsMYB1 transcription in modern tea cultivars that coincided with their higher galloylated cis‐catechins contents and trichome indexes.
Biochemical analyses and transgenic data showed that CsMYB1 interacted with CsGL3 and CsWD40 and formed a MYB‐bHLH‐WD40 (MBW) transcriptional complex to activate the trichome regulator genes CsGL2 and CsCPC, and the galloylated cis‐catechins biosynthesis genes anthocyanidin reductase and serine carboxypeptidase‐like 1A. CsMYB1 integratively regulated trichome formation and galloylated cis‐catechins biosynthesis.
Results suggest that CsMYB1, trichome and galloylated cis‐catechins are coincidently selected during tea domestication by harsh environments for improved adaption and by breeders for better tea flavours. |
| doi_str_mv | 10.1111/nph.18026 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9311817</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2629060955</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4436-74daa419d5dbbe35edae55d27fbb967a7d3b654b91ae350a740f3b5c853f17e3</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EotPCghdAltjQRVo7_ks2SDACilR-Fl3AyrLjm4mrxA52UjRvj-mUCpDwxgt_99O5Pgg9o-SMlnMe5uGMNqSWD9CGctlWDWXqIdoQUjeV5PLrETrO-ZoQ0gpZP0ZHTFCpKFUbFLb547c3FPuwwC6ZBTJeBsAJdutoFh8Djj1eku-GOAF2cANjnCcICzbB4a4MdIMPGVsf8z6U0exzkeEFDJ5HUzhXBvPiu1vbE_SoN2OGp3f3Cbp69_Zqe1Fdfn7_Yfv6suo4Z7JS3BnDaeuEsxaYAGdACFer3tpWKqMcs1Jw21JTXolRnPTMiq4RrKcK2Al6ddDOq53AdSVvMqOek59M2utovP77JfhB7-KNbhmlDVVF8PJOkOL3teTXk88djGUjiGvWtaxbIst3ioK--Ae9jmsKZbtCccGk4kIW6vRAdSnmnKC_D0OJ_lWiLiXq2xIL-_zP9Pfk79YKcH4AfvgR9v836U9fLg7Kn_h1qW4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645367456</pqid></control><display><type>article</type><title>CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Li, Penghui ; Fu, Jiamin ; Xu, Yujie ; Shen, Yihua ; Zhang, Yanrui ; Ye, Zhili ; Tong, Wei ; Zeng, Xiangsheng ; Yang, Jihong ; Tang, Dingkun ; Li, Ping ; Zuo, Hao ; Wu, Qiong ; Xia, Enhua ; Wang, Shucai ; Zhao, Jian</creator><creatorcontrib>Li, Penghui ; Fu, Jiamin ; Xu, Yujie ; Shen, Yihua ; Zhang, Yanrui ; Ye, Zhili ; Tong, Wei ; Zeng, Xiangsheng ; Yang, Jihong ; Tang, Dingkun ; Li, Ping ; Zuo, Hao ; Wu, Qiong ; Xia, Enhua ; Wang, Shucai ; Zhao, Jian</creatorcontrib><description>Summary
Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute to tea flavours, but little is known about the regulation of trichome development.
Here, we showed that CsMYB1 is involved in the regulation of trichome formation and galloylated cis‐catechins biosynthesis in tea plants. The variations in CsMYB1 expression levels are closely correlated with trichome indexes and galloylated cis‐catechins contents in tea plant populations. Genome resequencing showed that CsMYB1 may be selected in modern tea cultivars, since a 192‐bp insertion in CsMYB1 promoter was found exclusively in modern tea cultivars but not in the glabrous wild tea Camellia taliensis. Several enhancers in the 192‐bp insertion increased CsMYB1 transcription in modern tea cultivars that coincided with their higher galloylated cis‐catechins contents and trichome indexes.
Biochemical analyses and transgenic data showed that CsMYB1 interacted with CsGL3 and CsWD40 and formed a MYB‐bHLH‐WD40 (MBW) transcriptional complex to activate the trichome regulator genes CsGL2 and CsCPC, and the galloylated cis‐catechins biosynthesis genes anthocyanidin reductase and serine carboxypeptidase‐like 1A. CsMYB1 integratively regulated trichome formation and galloylated cis‐catechins biosynthesis.
Results suggest that CsMYB1, trichome and galloylated cis‐catechins are coincidently selected during tea domestication by harsh environments for improved adaption and by breeders for better tea flavours.</description><identifier>ISSN: 0028-646X</identifier><identifier>EISSN: 1469-8137</identifier><identifier>DOI: 10.1111/nph.18026</identifier><identifier>PMID: 35167117</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Anthocyanidin reductase ; Biosynthesis ; Camellia sinensis ; Carboxypeptidase ; Catechin ; Catechin - metabolism ; Cultivars ; Domestication ; Enhancers ; Environmental stress ; Flavors ; Flavour ; galloylated catechins ; Gene Expression Regulation, Plant ; Genes ; Genomes ; Harsh environments ; Insertion ; Metabolites ; Plant populations ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Reductases ; Serine ; Serine carboxypeptidase ; Tea ; tea plant population ; Transcription ; transcriptional regulation ; trichome development ; Trichomes ; Trichomes - metabolism</subject><ispartof>The New phytologist, 2022-05, Vol.234 (3), p.902-917</ispartof><rights>2022 The Authors. © 2022 New Phytologist Foundation</rights><rights>2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-74daa419d5dbbe35edae55d27fbb967a7d3b654b91ae350a740f3b5c853f17e3</citedby><cites>FETCH-LOGICAL-c4436-74daa419d5dbbe35edae55d27fbb967a7d3b654b91ae350a740f3b5c853f17e3</cites><orcidid>0000-0002-4416-7334</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35167117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Penghui</creatorcontrib><creatorcontrib>Fu, Jiamin</creatorcontrib><creatorcontrib>Xu, Yujie</creatorcontrib><creatorcontrib>Shen, Yihua</creatorcontrib><creatorcontrib>Zhang, Yanrui</creatorcontrib><creatorcontrib>Ye, Zhili</creatorcontrib><creatorcontrib>Tong, Wei</creatorcontrib><creatorcontrib>Zeng, Xiangsheng</creatorcontrib><creatorcontrib>Yang, Jihong</creatorcontrib><creatorcontrib>Tang, Dingkun</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Zuo, Hao</creatorcontrib><creatorcontrib>Wu, Qiong</creatorcontrib><creatorcontrib>Xia, Enhua</creatorcontrib><creatorcontrib>Wang, Shucai</creatorcontrib><creatorcontrib>Zhao, Jian</creatorcontrib><title>CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication</title><title>The New phytologist</title><addtitle>New Phytol</addtitle><description>Summary
Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute to tea flavours, but little is known about the regulation of trichome development.
Here, we showed that CsMYB1 is involved in the regulation of trichome formation and galloylated cis‐catechins biosynthesis in tea plants. The variations in CsMYB1 expression levels are closely correlated with trichome indexes and galloylated cis‐catechins contents in tea plant populations. Genome resequencing showed that CsMYB1 may be selected in modern tea cultivars, since a 192‐bp insertion in CsMYB1 promoter was found exclusively in modern tea cultivars but not in the glabrous wild tea Camellia taliensis. Several enhancers in the 192‐bp insertion increased CsMYB1 transcription in modern tea cultivars that coincided with their higher galloylated cis‐catechins contents and trichome indexes.
Biochemical analyses and transgenic data showed that CsMYB1 interacted with CsGL3 and CsWD40 and formed a MYB‐bHLH‐WD40 (MBW) transcriptional complex to activate the trichome regulator genes CsGL2 and CsCPC, and the galloylated cis‐catechins biosynthesis genes anthocyanidin reductase and serine carboxypeptidase‐like 1A. CsMYB1 integratively regulated trichome formation and galloylated cis‐catechins biosynthesis.
Results suggest that CsMYB1, trichome and galloylated cis‐catechins are coincidently selected during tea domestication by harsh environments for improved adaption and by breeders for better tea flavours.</description><subject>Anthocyanidin reductase</subject><subject>Biosynthesis</subject><subject>Camellia sinensis</subject><subject>Carboxypeptidase</subject><subject>Catechin</subject><subject>Catechin - metabolism</subject><subject>Cultivars</subject><subject>Domestication</subject><subject>Enhancers</subject><subject>Environmental stress</subject><subject>Flavors</subject><subject>Flavour</subject><subject>galloylated catechins</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genes</subject><subject>Genomes</subject><subject>Harsh environments</subject><subject>Insertion</subject><subject>Metabolites</subject><subject>Plant populations</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Reductases</subject><subject>Serine</subject><subject>Serine carboxypeptidase</subject><subject>Tea</subject><subject>tea plant population</subject><subject>Transcription</subject><subject>transcriptional regulation</subject><subject>trichome development</subject><subject>Trichomes</subject><subject>Trichomes - metabolism</subject><issn>0028-646X</issn><issn>1469-8137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kc1u1DAUhS0EotPCghdAltjQRVo7_ks2SDACilR-Fl3AyrLjm4mrxA52UjRvj-mUCpDwxgt_99O5Pgg9o-SMlnMe5uGMNqSWD9CGctlWDWXqIdoQUjeV5PLrETrO-ZoQ0gpZP0ZHTFCpKFUbFLb547c3FPuwwC6ZBTJeBsAJdutoFh8Djj1eku-GOAF2cANjnCcICzbB4a4MdIMPGVsf8z6U0exzkeEFDJ5HUzhXBvPiu1vbE_SoN2OGp3f3Cbp69_Zqe1Fdfn7_Yfv6suo4Z7JS3BnDaeuEsxaYAGdACFer3tpWKqMcs1Jw21JTXolRnPTMiq4RrKcK2Al6ddDOq53AdSVvMqOek59M2utovP77JfhB7-KNbhmlDVVF8PJOkOL3teTXk88djGUjiGvWtaxbIst3ioK--Ae9jmsKZbtCccGk4kIW6vRAdSnmnKC_D0OJ_lWiLiXq2xIL-_zP9Pfk79YKcH4AfvgR9v836U9fLg7Kn_h1qW4</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Li, Penghui</creator><creator>Fu, Jiamin</creator><creator>Xu, Yujie</creator><creator>Shen, Yihua</creator><creator>Zhang, Yanrui</creator><creator>Ye, Zhili</creator><creator>Tong, Wei</creator><creator>Zeng, Xiangsheng</creator><creator>Yang, Jihong</creator><creator>Tang, Dingkun</creator><creator>Li, Ping</creator><creator>Zuo, Hao</creator><creator>Wu, Qiong</creator><creator>Xia, Enhua</creator><creator>Wang, Shucai</creator><creator>Zhao, Jian</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4416-7334</orcidid></search><sort><creationdate>202205</creationdate><title>CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication</title><author>Li, Penghui ; Fu, Jiamin ; Xu, Yujie ; Shen, Yihua ; Zhang, Yanrui ; Ye, Zhili ; Tong, Wei ; Zeng, Xiangsheng ; Yang, Jihong ; Tang, Dingkun ; Li, Ping ; Zuo, Hao ; Wu, Qiong ; Xia, Enhua ; Wang, Shucai ; Zhao, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-74daa419d5dbbe35edae55d27fbb967a7d3b654b91ae350a740f3b5c853f17e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anthocyanidin reductase</topic><topic>Biosynthesis</topic><topic>Camellia sinensis</topic><topic>Carboxypeptidase</topic><topic>Catechin</topic><topic>Catechin - metabolism</topic><topic>Cultivars</topic><topic>Domestication</topic><topic>Enhancers</topic><topic>Environmental stress</topic><topic>Flavors</topic><topic>Flavour</topic><topic>galloylated catechins</topic><topic>Gene Expression Regulation, Plant</topic><topic>Genes</topic><topic>Genomes</topic><topic>Harsh environments</topic><topic>Insertion</topic><topic>Metabolites</topic><topic>Plant populations</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Reductases</topic><topic>Serine</topic><topic>Serine carboxypeptidase</topic><topic>Tea</topic><topic>tea plant population</topic><topic>Transcription</topic><topic>transcriptional regulation</topic><topic>trichome development</topic><topic>Trichomes</topic><topic>Trichomes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Penghui</creatorcontrib><creatorcontrib>Fu, Jiamin</creatorcontrib><creatorcontrib>Xu, Yujie</creatorcontrib><creatorcontrib>Shen, Yihua</creatorcontrib><creatorcontrib>Zhang, Yanrui</creatorcontrib><creatorcontrib>Ye, Zhili</creatorcontrib><creatorcontrib>Tong, Wei</creatorcontrib><creatorcontrib>Zeng, Xiangsheng</creatorcontrib><creatorcontrib>Yang, Jihong</creatorcontrib><creatorcontrib>Tang, Dingkun</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Zuo, Hao</creatorcontrib><creatorcontrib>Wu, Qiong</creatorcontrib><creatorcontrib>Xia, Enhua</creatorcontrib><creatorcontrib>Wang, Shucai</creatorcontrib><creatorcontrib>Zhao, Jian</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New phytologist</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Penghui</au><au>Fu, Jiamin</au><au>Xu, Yujie</au><au>Shen, Yihua</au><au>Zhang, Yanrui</au><au>Ye, Zhili</au><au>Tong, Wei</au><au>Zeng, Xiangsheng</au><au>Yang, Jihong</au><au>Tang, Dingkun</au><au>Li, Ping</au><au>Zuo, Hao</au><au>Wu, Qiong</au><au>Xia, Enhua</au><au>Wang, Shucai</au><au>Zhao, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication</atitle><jtitle>The New phytologist</jtitle><addtitle>New Phytol</addtitle><date>2022-05</date><risdate>2022</risdate><volume>234</volume><issue>3</issue><spage>902</spage><epage>917</epage><pages>902-917</pages><issn>0028-646X</issn><eissn>1469-8137</eissn><abstract>Summary
Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute to tea flavours, but little is known about the regulation of trichome development.
Here, we showed that CsMYB1 is involved in the regulation of trichome formation and galloylated cis‐catechins biosynthesis in tea plants. The variations in CsMYB1 expression levels are closely correlated with trichome indexes and galloylated cis‐catechins contents in tea plant populations. Genome resequencing showed that CsMYB1 may be selected in modern tea cultivars, since a 192‐bp insertion in CsMYB1 promoter was found exclusively in modern tea cultivars but not in the glabrous wild tea Camellia taliensis. Several enhancers in the 192‐bp insertion increased CsMYB1 transcription in modern tea cultivars that coincided with their higher galloylated cis‐catechins contents and trichome indexes.
Biochemical analyses and transgenic data showed that CsMYB1 interacted with CsGL3 and CsWD40 and formed a MYB‐bHLH‐WD40 (MBW) transcriptional complex to activate the trichome regulator genes CsGL2 and CsCPC, and the galloylated cis‐catechins biosynthesis genes anthocyanidin reductase and serine carboxypeptidase‐like 1A. CsMYB1 integratively regulated trichome formation and galloylated cis‐catechins biosynthesis.
Results suggest that CsMYB1, trichome and galloylated cis‐catechins are coincidently selected during tea domestication by harsh environments for improved adaption and by breeders for better tea flavours.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35167117</pmid><doi>10.1111/nph.18026</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-4416-7334</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The New phytologist, 2022-05, Vol.234 (3), p.902-917 |
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| subjects | Anthocyanidin reductase Biosynthesis Camellia sinensis Carboxypeptidase Catechin Catechin - metabolism Cultivars Domestication Enhancers Environmental stress Flavors Flavour galloylated catechins Gene Expression Regulation, Plant Genes Genomes Harsh environments Insertion Metabolites Plant populations Plant Proteins - genetics Plant Proteins - metabolism Reductases Serine Serine carboxypeptidase Tea tea plant population Transcription transcriptional regulation trichome development Trichomes Trichomes - metabolism |
| title | CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication |
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