Efficacy of different sentinel lymph node biopsy protocols in oral squamous cell carcinoma: Systematic review and meta‐analysis

The sentinel node biopsy (SNB) is highly protocolized in other cancers, however, this is not the case for oral squamous cell carcinoma patients, hence our objective was to evaluate the different protocols published. A specific study protocol was designed and subsequently registered on PROSPERO (Ref....

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Bibliographic Details
Published in:Head & neck 2022-07, Vol.44 (7), p.1702-1714
Main Authors: Suárez Ajuria, Maria, Gallas Torreira, Mercedes, García García, Abel, Marichalar Mendía, Xabier, Chamorro Petronacci, Cintia M., Padín Iruegas, Elena, Pérez Sayáns, Mario
Format: Article
Language:English
Subjects:
Biopsy
blue dye
Clinical Review
Clinical Reviews
Dyes
indocyanine green
Lymph nodes
Meta-analysis
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
protocols
sentinel node lymph biopsy
Squamous cell carcinoma
systematic review
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Summary:The sentinel node biopsy (SNB) is highly protocolized in other cancers, however, this is not the case for oral squamous cell carcinoma patients, hence our objective was to evaluate the different protocols published. A specific study protocol was designed and subsequently registered on PROSPERO (Ref. CRD42021279217). Twenty‐three articles were included in the meta‐analysis. The grouped sensitivity of the SNB was 82% (95% CI: 0.74–0.88), and the grouped specificity was 100% (95% CI: 0.99–1.00). The use of other radiotracers other than pre‐operative lopamidol showed higher values of sensitivity of 82.80% (95% CI: 76.90%–87.50%; p 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.27042