Identification of New Toxicity Mechanisms in Drug-Induced Liver Injury through Systems Pharmacology

Among adverse drug reactions, drug-induced liver injury presents particular challenges because of its complexity, and the underlying mechanisms are still not completely characterized. Our knowledge of the topic is limited and based on the assumption that a drug acts on one molecular target. We have...

Full description

Saved in:
Bibliographic Details
Published in:Genes 2022-07, Vol.13 (7), p.1292
Main Authors: Moya-García, Aurelio A., González-Jiménez, Andrés, Moreno, Fernando, Stephens, Camilla, Lucena, María Isabel, Ranea, Juan A. G.
Format: Article
Language:English
Subjects:
Binding sites
Biological products
Drugs
Ligands
Liver
Metabolism
Molecular modelling
Pharmaceutical industry
Pharmacology
Proteins
Toxicity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Among adverse drug reactions, drug-induced liver injury presents particular challenges because of its complexity, and the underlying mechanisms are still not completely characterized. Our knowledge of the topic is limited and based on the assumption that a drug acts on one molecular target. We have leveraged drug polypharmacology, i.e., the ability of a drug to bind multiple targets and thus perturb several biological processes, to develop a systems pharmacology platform that integrates all drug–target interactions. Our analysis sheds light on the molecular mechanisms of drugs involved in drug-induced liver injury and provides new hypotheses to study this phenomenon.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13071292