Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month

Chronic kidney disease (CKD) is a critical complication of liver transplants, of which non-renal risk factors are not fully understood yet. This study aimed to reveal pre- and post-transplant risk factors for CKD (

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Published in:Journal of clinical medicine 2022-07, Vol.11 (14), p.4203
Main Authors: Kim, Deok-Gie, Hwang, Shin, Kim, Jong Man, Ryu, Je Ho, You, Young Kyoung, Choi, Donglak, Kim, Bong-Wan, Kim, Dong-Sik, Nah, Yang Won, Kim, Tae-Seok, Cho, Jai Young, Hong, Geun, Yang, Jae Do, Han, Jaryung, Suh, Suk-Won, Kim, Kwan Woo, Jung, Yun Kyung, Moon, Ju Ik, Lee, Jun Young, Kim, Sung Hwa, Lee, Jae Geun, Kim, Myoung Soo, Lee, Kwang-Woong, Joo, Dong Jin
Format: Article
Language:English
Subjects:
Clinical medicine
Hemodialysis
Kidney diseases
Kidney transplants
Laboratories
Liver cancer
Liver diseases
Liver transplants
Patients
Population
Risk factors
Variables
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cited_by cdi_FETCH-LOGICAL-c409t-4e04592bc3518ab857fc3684c09ccb5af4f9f48ff9e316287019feaa31d73b903
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container_issue 14
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container_title Journal of clinical medicine
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creator Kim, Deok-Gie
Hwang, Shin
Kim, Jong Man
Ryu, Je Ho
You, Young Kyoung
Choi, Donglak
Kim, Bong-Wan
Kim, Dong-Sik
Nah, Yang Won
Kim, Tae-Seok
Cho, Jai Young
Hong, Geun
Yang, Jae Do
Han, Jaryung
Suh, Suk-Won
Kim, Kwan Woo
Jung, Yun Kyung
Moon, Ju Ik
Lee, Jun Young
Kim, Sung Hwa
Lee, Jae Geun
Kim, Myoung Soo
Lee, Kwang-Woong
Joo, Dong Jin
description Chronic kidney disease (CKD) is a critical complication of liver transplants, of which non-renal risk factors are not fully understood yet. This study aimed to reveal pre- and post-transplant risk factors for CKD (
doi_str_mv 10.3390/jcm11144203
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This study aimed to reveal pre- and post-transplant risk factors for CKD (&lt;60 mL/min/1.73 m2), examining liver recipients with functionally intact kidneys one month after grafting using nationwide cohort data. Baseline risk factors were analyzed with multivariable Cox regression analyses and post-transplant risk factors were investigated with the time-dependent Cox model and matched analyses of time-conditional propensity scores. Of the 2274 recipients with a one-month eGFR ≥ 60 mL/min/1.73 m2, 494 (22.3%) developed CKD during a mean follow-up of 36.6 ± 14.4 months. Age, female sex, lower body mass index, pre-transplant diabetes mellitus, and lower performance status emerged as baseline risk factors for CKD. Time-dependent Cox analyses revealed that recurrent hepatocellular carcinoma (HR = 1.93, 95% CI 1.06−3.53) and infection (HR = 1.44, 95% CI 1.12−1.60) were significant post-transplant risk factors for CKD. Patients who experienced one of those factors showed a significantly higher risk of subsequent CKD compared with the matched controls who lacked these features (p = 0.013 for recurrent hepatocellular carcinoma, and p = 0.003 for infection, respectively). This study clarifies pre- and post-transplant non-renal risk factors, which lead to renal impairment after LT independently from patients’ renal functional reserve.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11144203</identifier><identifier>PMID: 35887972</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Clinical medicine ; Hemodialysis ; Kidney diseases ; Kidney transplants ; Laboratories ; Liver cancer ; Liver diseases ; Liver transplants ; Patients ; Population ; Risk factors ; Variables</subject><ispartof>Journal of clinical medicine, 2022-07, Vol.11 (14), p.4203</ispartof><rights>2022 by the authors. 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subjects Clinical medicine
Hemodialysis
Kidney diseases
Kidney transplants
Laboratories
Liver cancer
Liver diseases
Liver transplants
Patients
Population
Risk factors
Variables
title Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month
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