C‐Nitrosothioformamide: A Donor Template for Dual Release of HNO and H2S

C‐Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro‐Diels‐Alder reaction. COS is an H2S precursor in the presence of carbonic anhydrase. This process produces HNO and H2S in a slow but steady manner. As such, the direct reaction between...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2022-07, Vol.23 (13), p.e202200101-n/a
Main Authors: Kelly, Shane S., Ni, Xiang, Yuen, Vivian, Radford, Miles N., Xian, Ming
Format: Article
Language:English
Subjects:
Carbonic anhydrase
Carbonic anhydrases
donors
Hydrogen sulfide
nitric oxide
nitroxyl
retro-Diels Alder reaction
Synergistic effect
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Summary:C‐Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro‐Diels‐Alder reaction. COS is an H2S precursor in the presence of carbonic anhydrase. This process produces HNO and H2S in a slow but steady manner. As such, the direct reaction between HNO and H2S under this situation appears to be minor. This may provide a useful tool for studying the synergistic effects of HNO and H2S. A retro‐Diels‐Alder reaction triggered dual release of H2S and HNO from C‐nitrosothioformamides is reported. This process produces HNO and COS concurrently. COS can be further converted to H2S by carbonic anhydrase. These donors may be useful to understanding the crosstalk between H2S and HNO.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202200101