Dietary Patterns and Prostate Cancer: CAPLIFE Study

The etiology of prostate cancer (PCa) remains uncertain, and the role of diet is unclear. We aimed to evaluate the role of diet, through dietary patterns, on PCa, considering tumor aggressiveness and extension. The CAPLIFE study is a population-based case-control study including a total of 428 incid...

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Published in:Cancers 2022-07, Vol.14 (14), p.3475
Main Authors: Lozano-Lorca, Macarena, Rodríguez-González, Margarita, Salcedo-Bellido, Inmaculada, Vázquez-Alonso, Fernando, Arrabal, Miguel, Martín-Castaño, Benita, Sánchez, María-José, Jiménez-Moleón, José-Juan, Olmedo-Requena, Rocío
Format: Article
Language:English
Subjects:
Angina pectoris
Diet
Etiology
Family medical history
Food
Hospitals
Medical research
Nutrients
Population
Population studies
Principal components analysis
Prostate cancer
Questionnaires
Regression analysis
Smoking
Tumors
Vitamins
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Summary:The etiology of prostate cancer (PCa) remains uncertain, and the role of diet is unclear. We aimed to evaluate the role of diet, through dietary patterns, on PCa, considering tumor aggressiveness and extension. The CAPLIFE study is a population-based case-control study including a total of 428 incident PCa cases and 393 controls aged 40–80 years. Dietary information was collected through a validated food frequency questionnaire. Three dietary patterns were identified through principal component analysis: “Mediterranean,” “Western,” and “Unhealthy,” which were categorized into tertiles according to the control group cutoff points. Tumor aggressiveness and extension was determined. Logistic regression models were used to assess the association between dietary patterns and PCa. High adherence to an unhealthy dietary pattern was associated with higher odds of PCa, ORT3vsT1 = 1.52 (95% CI 1.02–2.27), especially for cases with ISUP 1–2 and localized PCa tumors. This association was not observed with a Western or Mediterranean pattern. In conclusion, adherence to an unhealthy diet appears to be associated with higher odds of PCa, especially for cases with ISUP 1–2 and localized PCa tumors.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14143475