Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans

This study evaluated whether glomerular hyperfiltration (GHF) could predict nonalcoholic fatty liver disease (NAFLD) and fibrosis. A longitudinal cohort study including 147,479 participants aged 20–65 years without NAFLD and kidney disease at baseline was performed. GHF cutoff values were defined as...

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Published in:Journal of personalized medicine 2022-07, Vol.12 (7), p.1142
Main Authors: Koo, Dae-Jeong, Lee, Mi Yeon, Jung, Inha, Moon, Sun Joon, Kwon, Hyemi, Rhee, Eun-Jung, Park, Cheol-Young, Lee, Won-Young, Oh, Ki Won, Park, Se Eun
Format: Article
Language:English
Subjects:
Abdomen
Age
Body mass index
Cardiovascular disease
Cholesterol
Cohort analysis
Diabetes
Diabetes mellitus
Epidermal growth factor receptors
Exercise
Fasting
Fatty liver
Fibrosis
Gene expression
Glomerular filtration rate
Hepatitis
Hypertension
Kidney diseases
Liver diseases
Longitudinal studies
Metabolism
Physical fitness
Precision medicine
Questionnaires
Variance analysis
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Summary:This study evaluated whether glomerular hyperfiltration (GHF) could predict nonalcoholic fatty liver disease (NAFLD) and fibrosis. A longitudinal cohort study including 147,479 participants aged 20–65 years without NAFLD and kidney disease at baseline was performed. GHF cutoff values were defined as age- and sex-specific estimated glomerular filtration rate (eGFRs) above the 95th percentile, and eGFR values between the 50th and 65th percentiles were used as reference groups. NAFLD was diagnosed via abdominal ultrasonography, and the fibrosis status was evaluated using the NAFLD fibrosis score and Fibrosis-4. During 598,745 person years of follow-up (median, 4.6 years), subjects with GHF at baseline had the highest hazard ratio (HR) for the development of NAFLD (HR 1.21; 95% CI 1.14–1.29) and fibrosis progression (HR 1.42; 95% CI 1.11–1.82) after adjusting for confounding factors. A higher baseline eGFR percentile maintained a higher risk of NAFLD and fibrosis probability. The persistent GHF group during follow-up had the highest HR for NAFLD compared to the persistent non-GHF group (HR 1.31; 95% CI 1.14–1.51). These results were consistent in all subgroups and statistically more prominent in participants without diabetes. GHF was positively associated with increased risk of NAFLD and probability of liver fibrosis in healthy adults.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12071142