Inhibition of the Sec61 translocon overcomes cytokine‐induced glucocorticoid resistance in T‐cell acute lymphoblastic leukaemia

Glucocorticoid (GC) resistance is a poor prognostic factor in T‐cell acute lymphoblastic leukaemia (T‐ALL). Interleukin‐7 (IL‐7) mediates GC resistance via GC‐induced upregulation of IL‐7 receptor (IL‐7R) expression, leading to increased pro‐survival signalling. IL‐7R reaches the cell surface via th...

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Bibliographic Details
Published in:British journal of haematology 2022-07, Vol.198 (1), p.137-141
Main Authors: Meyer, Lauren K., Delgado‐Martin, Cristina, Sharp, Phillip P., Huang, Benjamin J., McMinn, Dustin, Vincent, Tiffaney L., Ryan, Theresa, Horton, Terzah M., Wood, Brent L., Teachey, David T., Taunton, Jack, Kirk, Christopher J., Hermiston, Michelle L.
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Cell surface
cytokine
Dexamethasone
Endoplasmic reticulum
Glucocorticoids
Haematological Malignancy‐biology
Hematology
Sec61 inhibitor
Short Report
Signal transduction
T‐cell acute lymphoblastic leukaemia
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Summary:Glucocorticoid (GC) resistance is a poor prognostic factor in T‐cell acute lymphoblastic leukaemia (T‐ALL). Interleukin‐7 (IL‐7) mediates GC resistance via GC‐induced upregulation of IL‐7 receptor (IL‐7R) expression, leading to increased pro‐survival signalling. IL‐7R reaches the cell surface via the secretory pathway, so we hypothesized that inhibiting the translocation of IL‐7R into the secretory pathway would overcome GC resistance. Sec61 is an endoplasmic reticulum (ER) channel that is required for insertion of polypeptides into the ER. Here, we demonstrate that KZR‐445, a novel inhibitor of Sec61, potently attenuates the dexamethasone (DEX)‐induced increase in cell surface IL‐7R and overcomes IL‐7‐induced DEX resistance.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18181