Treatments in psoriasis: from standard pharmacotherapy to nanotechnology therapy

Psoriasis is a genetic chronic disease mediated by the immune system with systemic and cutaneous manifestations that can significantly deteriorate patients' quality of life. Two-three percent of the population worldwide suffer from psoriasis and it imposes a substantial economic burden on patie...

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Bibliographic Details
Published in:Postȩpy dermatologii i alergologii 2022-01, Vol.39 (3), p.460-471
Main Authors: Zhu, Baohua, Jing, Mingyi, Yu, Qianying, Ge, Xiaopei, Yuan, Fan, Shi, Lanhui
Format: Article
Language:English
Subjects:
Antigens
Chinese medicine
Chronic illnesses
Cytokines
Dermatology
Disease
Drug dosages
Drug therapy
Epidemiology
Immune system
Light therapy
Lymphocytes
Nanotechnology
Pathophysiology
Patients
Peptides
Psoriasis
Quality of life
Review Paper
Skin
Steroids
Vitamin D
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Summary:Psoriasis is a genetic chronic disease mediated by the immune system with systemic and cutaneous manifestations that can significantly deteriorate patients' quality of life. Two-three percent of the population worldwide suffer from psoriasis and it imposes a substantial economic burden on patients. The aetiology is mainly related with genes and environmental factors. The pathophysiology of psoriasis is characterized by T cells and dendritic cells, antimicrobial peptides, genetic predispositions, lipoprotein-2, galactosin-3, fractalkine, vaspin, and human neutrophilic peptides, etc. in the progression of psoriasis. For patients with psoriasis, the traditional treatments include corticosteroids, vitamin D analogues, calcineurin inhibitors, methotrexate, cyclosporine, acitretin, phototherapy, and biological agents, etc. Nanodermatology is an emerging, multidisciplinary science that is gaining increasing recognition in the treatment of psoriasis. This review provides a summary of the pathophysiology, epidemiology, clinical diagnosis, and classical pharmacotherapy of psoriasis. The review also summarizes different nanotechnology therapies for effective treatment of psoriasis.
ISSN:1642-395X
2299-0046
DOI:10.5114/ada.2021.108445