The ISHLT Chronic Lung Allograft Dysfunction Consensus Criteria is Applicable to Pulmonary Chronic Graft-versus-Host Disease

Pulmonary chronic graft-versus-host disease (PcGvHD) is a devastating complication of allogeneic hematopoietic stem cell transplant (HCT). The 2014 NIH chronic GvHD (cGvHD) Consensus Criteria (NIH Criteria) only captures bronchiolitis obliterans syndrome (BOS). In this study, we adapted the 2019 Cri...

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Bibliographic Details
Published in:Blood advances 2022-07, Vol.6 (14), p.4196-4207
Main Authors: Pang, Yifan, Charya, Ananth V, Keller, Michael B, Sirajuddin, Arlene, Fu, Yi-Ping, Holtzman, Noa G, Pavletic, Steven Z, Agbor-Enoh, Sean
Format: Article
Language:English
Subjects:
Transplantation
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Summary:Pulmonary chronic graft-versus-host disease (PcGvHD) is a devastating complication of allogeneic hematopoietic stem cell transplant (HCT). The 2014 NIH chronic GvHD (cGvHD) Consensus Criteria (NIH Criteria) only captures bronchiolitis obliterans syndrome (BOS). In this study, we adapted the 2019 Criteria of chronic lung allograft dysfunction (CLAD) to define novel phenotypes of PcGvHD and compared the performance of this criteria with the NIH Criteria to identify high-risk PcGvHD patients. We reviewed consecutive patients in a cGvHD natural history protocol (NCT00092235) and adapted the 2019 CLAD Criteria (the Adapted Criteria) to define PcGvHD as post-HCT FEV1
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2021006885