Simultaneous pancreas-kidney transplantation: Early complications and long-term outcomes - a single-centre experience

This study aimed to assess the prevalence and severity of complications after simultaneous pancreas-kidney transplantation (SPKT) and to evaluate its influence on both grafts' long-term results. This was an observational, retrospective study including 39 consecutive SPKT cases from 2000-2018. C...

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Bibliographic Details
Published in:Canadian Urological Association journal 2022-07, Vol.16 (7), p.E357-E362
Main Authors: Crespo, Natalia Vidal, Cubillana, Pedro López, López González, Pedro A, Alarcón, Cristóbal Moreno, Hernández, Javier Rull, Martínez, Laura Aznar, Abad, Alicia López, Fernández Garay, Juan C, Muñoz, Rocío Martínez, Viñas, Santiago Llorente, Fernández Hernández, Juan A, Gómez Gómez, Guillermo A
Format: Article
Language:English
Subjects:
Care and treatment
Chronic kidney failure
Complications
Kidneys
Original Research
Pancreatic beta cells
Patient outcomes
Prognosis
Surgery
Transplantation
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Summary:This study aimed to assess the prevalence and severity of complications after simultaneous pancreas-kidney transplantation (SPKT) and to evaluate its influence on both grafts' long-term results. This was an observational, retrospective study including 39 consecutive SPKT cases from 2000-2018. Complications were classified into kidney-related and pancreas-related. The severity of complications was assessed using the modified Clavien-Dindo scale. Kaplan-Meier curve analysis and log-rank tests were used. Cox regression was performed for the multivariate analysis. All 39 recipients had long-term type I diabetes. Twenty-one (53.8%) patients suffered a Clavien-Dindo ≥IIIa complication. Most complications were pancreas-related, with 17 (43.6%) patients suffering from one. Kidney-related major complications were seen in 11 (28.2%) patients. Patient survival at one, five, and 15 years was 89.7%, 87.1%, and 83.9%, respectively; kidney survival was 87.1%, 81.4%, and 73.6%, respectively; and pancreas survival was 76.9%, 71.3%, and 72%, respectively. Pancreas graft survival was influenced by the presence of major postoperative complications; patients and kidney graft survival were not. Complications after SPKT influence pancreas graft survival. Despite the high rate of complications, our results suggest that patients' and kidney graft survival may not be affected by complications.
ISSN:1911-6470
1920-1214
DOI:10.5489/cuaj.7635